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CREB1 / CREB

cAMP responsive element binding protein 1

CREB (cAMP response element binding protein1), a DNA binding protein, is a member of the leucine zipper family of transcription factors. CREB interaction with DNA requires phosphorylation at Ser 119 by activated cAMP protein kinase A. Once phosphorylated CREB binds to an 8 base enhancer know as the cAMP response element (CRE) containing a conserved core sequence TGACG. CREB also interacts with CBP (CREB binding protein) and RNA polymerase II when phosphorylated on Ser 133. Different isoforms of this protein are the result of two transcript variants.

Gene Name:	cAMP responsive element binding protein 1
Family/Subfamily:	Transcription factor , not assigned-Transcription factor
Synonyms:	CREB1, CREB-1, Transactivator protein, CREB
Target Sequences:	NM_134442 NP_004370.1 P16220

Publications (8)

Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:5898-903. [PubMed:15073328] [PMC:PMC395895]

Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo. Shi Y, Dodson GE, Shaikh S, Rundell K, Tibbetts RS. The Journal of biological chemistry. 2005 280:40195-200. [PubMed:16221684]

DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. Dodson GE, Tibbetts RS. The Journal of biological chemistry. 2006 281:1692-7. [PubMed:16293623]

Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage. Shanware NP, Trinh AT, Williams LM, Tibbetts RS. The Journal of biological chemistry. 2007 282:6283-91. [PubMed:17209043]

Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. Shi Y, Dodson GE, Mukhopadhyay PS, Shanware NP, Trinh AT, Tibbetts RS. The Journal of biological chemistry. 2007 282:9236-43. [PubMed:17244605]

Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway. Wang D, Guo MX, Hu HM, Zhao ZZ, Qiu HL, Shao HJ, Zhu CG, Xue L, Shi YB, Li WX. The Journal of biological chemistry. 2008 283:16299-308. (GS) [PubMed:18375384] [PMC:PMC2423250]

Synaptic tagging and capture: differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation. Redondo RL, Okuno H, Spooner PA, Frenguelli BG, Bito H, Morris RG. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 30:4981-9. (ICC) [PubMed:20371818]

Severe reaction to radiotherapy for breast cancer as the presenting feature of ataxia telangiectasia. Byrd PJ, Srinivasan V, Last JI, Smith A, Biggs P, Carney EF, Exley A, Abson C, Stewart GS, Izatt L, Taylor AM. British journal of cancer. 2012 106:262-8. [PubMed:22146522] [PMC:PMC3261689]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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