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CRD / CRX

cone-rod homeobox

Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.

Gene Name:	cone-rod homeobox
Synonyms:	CRX, Cone-rod homeobox protein, CRD, LCA7, OTX3, Cone-rod homeobox, CORD2, Orthodenticle homeobox 3
Target Sequences:	NM_000554 NP_000545.1 O43186

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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