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CRBN / Cereblon

cereblon

Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.

Gene Name: cereblon
Synonyms: CRBN, Cereblon, MRT2, MRT2A, Protein x 0001, Protein cereblon
Target Sequences: NM_016302 NP_057386.2 Q96SW2

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Products
Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
CRBN / Cereblon (9)
No (9)
10His, N-terminus + Myc, C-terminus (1)
6His, C-terminus (1)
6His, N-terminus (1)
6His-B2M, N-terminus (1)
9His, C-terminus (1)
GST, N-terminus (2)
Myc-DDK (Flag) (2)
Human (7)
Mouse (1)
293T Cells (1)
Baculovirus (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Yeast (1)
Purified (6)
CRBN / Cereblon Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
100 µg/$1,128; 20 µg/$721
CRBN / Cereblon Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Baculovirus
9His, C-terminus
100 µg/$1,067; 20 µg/$447; 500 µg/$1,396; 1 mg/$1,988
CRBN / Cereblon Protein - 12.5% SDS-PAGE of human CRBN stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
76.9 kDa
10 µg/$479; 25 µg/$670
CRBN / Cereblon Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
10His, N-terminus + Myc, C-terminus
100 µg/$499; 20 µg/$364; 1 mg/$1,683
CRBN / Cereblon Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-B2M, N-terminus
64.5 kDa
100 µg/$1,128; 20 µg/$721
CRBN / Cereblon Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
50.5 kDa
20 µg/$150
CRBN / Cereblon Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, C-terminus
100 µg/$1,128; 20 µg/$721
CRBN / Cereblon Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CRBN / Cereblon Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
50.5 kDa
100 µg/$494
Viewing 1-9 of 9 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).