CRACR2A / EFCAB4B

EF-hand calcium binding domain 4B

Ca2+-binding protein that plays a key role in store-operated Ca2+ entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+ resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

CRACR2A / EFCAB4B (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human CRACR2A / EFCAB4B Protein (Recombinant GST) (Full Length) - LS-G35822

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72 kDa

Price:

10 µg/$479; 25 µg/$670

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CRACR2A / EFCAB4B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108675

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

100 µg/$494

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Human CRACR2A / EFCAB4B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72404

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

20 µg/$1,107

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Human CRACR2A / EFCAB4B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92260

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

20 µg/$150

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