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CRACR2A / EFCAB4B
EF-hand calcium binding domain 4B
Ca2+-binding protein that plays a key role in store-operated Ca2+ entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+ resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
| Gene Name: | EF-hand calcium binding domain 4B |
| Synonyms: | CRACR2A, CRAC channel regulator 2A, EFCAB4B |
| Target Sequences: | NM_032680 NP_116069.1 Q9BSW2 |
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