CPSF3 / CPSF

cleavage and polyadenylation specific factor 3, 73kDa

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.

☰ Filters

Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

CPSF3 / CPSF (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

CPSF3 / CPSF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112794

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.3 kDa

Price:

100 µg/$494

Select

Human CPSF3 / CPSF Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90284

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.3 kDa

Price:

20 µg/$150

Select

Human CPSF3 / CPSF Protein (Recombinant GST) (Full Length) - LS-G33871

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

103.9 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human CPSF3 / CPSF Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71647

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.3 kDa

Price:

20 µg/$1,107

Select

Human CPSF3 / CPSF Protein (Recombinant GST, N-terminus) (aa585-684) - LS-G62517

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Viewing 1-5 of 5 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.