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CPN1

carboxypeptidase N, polypeptide 1

Carboxypeptidase N (CPN)is a plasma metallo-protease that cleaves basic amino acid residues from the C terminal of peptides and proteins. The enzyme plays a central role in regulating the biologic activity of peptides such as kinins and anaphylatoxins, and is also known as kininase-1 and anaphylatoxin inactivator. CPN is a tetrameric complex with a molecular weight of 280-kD consisting of two identical small enzymatically active (catalytic) subunits of 50-kD (this record) and two large 83-kD regulatory subunits. The gene that encodes the 50-kD catalytic subunit has been mapped to chromosome 10 but its exact location is unknown.

Gene Name: carboxypeptidase N, polypeptide 1
Family/Subfamily: Exopeptidase , Metallopeptidase M14
Synonyms: CPN1, ACBP, Arginine carboxypeptidase, Anaphylatoxin inactivator, Carboxypeptidase K, Kininase-1, Lysine carboxypeptidase, Kininase I, Serum carboxypeptidase N, SCPN, Plasma carboxypeptidase B, CPN
Target Sequences: NM_001308 NP_001299.1 P15169

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
CPN1 (6)
No (6)
6His, N-terminus (1)
GST (1)
His, N-Terminal (1)
His-GST (1)
Myc-DDK (Flag) (2)
Human (4)
Mouse (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
CPN1 Protein
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E. coli
His, N-Terminal
50 kDa
50 µg/$419
CPN1 Protein - Recombinant Carboxypeptidase N1 By SDS-PAGE
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E. coli
6His, N-terminus
21.1 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
CPN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
52.29 kDa
100 µg/$494
CPN1 Protein - 12.5% SDS-PAGE of human CPN1 stained with Coomassie Blue
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Wheat Germ Extract
GST
78.7 kDa
2 µg/$439
CPN1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
52.29 kDa
20 µg/$150
CPN1 Protein - Recombinant Carboxypeptidase N1 By SDS-PAGE
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E. coli
His-GST
57.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).