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CPLX1 / Complexin 1

complexin 1

Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells.

Gene Name:	complexin 1
Synonyms:	CPLX1, Complexin-1, CPX I, Complexin 1, CPX-I, Synaphin-2, Synaphin 2, Complexin I, CPX1
Target Sequences:	NM_006651 NP_006642.1 O14810

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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