Carboxypeptidase E / CPE is a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
|Gene Name:||carboxypeptidase E|
|Family/Subfamily:||Exopeptidase , Metallopeptidase M14|
|Synonyms:||CPE, Carboxypeptidase E, CPH, Carboxypeptidase H, Enkephalin convertase|
|Target Sequences:||NM_001873 NP_001864.1 P16870|
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