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CPA3

carboxypeptidase A3 (mast cell)

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A3 form, is obtained as a binary complex of a procarboxypeptidase A with a proproteinase E. Mast cell carboxypeptidase A is a secretory granule metalloexopeptidase that has a pH optimum in the neutral to basic range. It resembles pancreatic carboxypeptidase A in cleaving COOH-terminal aromatic and aliphatic amino acid residues.

Gene Name: carboxypeptidase A3 (mast cell)
Family/Subfamily: Exopeptidase , Metallopeptidase M14
Synonyms: CPA3, Carboxypeptidase A3, Mast cell carboxypeptidase A, MC-CPA, Tissue carboxypeptidase A
Target Sequences: NM_001870 NP_001861.2 P15088

Publications (2)

1
Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody. Simon Gebremeskel, Julia Schanin, Krysta M Coyle, Melina Butuci, Thuy Luu, Emily C Brock, Alan Xu, Alan Wong, John Leung, Wouter Korver, Ryan D Morin, Robert P Schleimer, Bruce S Bochner, Bradford A Youngblood. Frontiers in immunology. 2021 March;12:650331. [Full Text Article] [PubMed:33777047] [PMC:PMC7988091]
2
Severity of SARS-CoV-2 infection is associated with high numbers of alveolar mast cells and their degranulation. Olga Krysko, Joshua H Bourne, Elena Kondakova, Elena A Galova, Katharine Whitworth, Maddy L Newby, Claus Bachert, Harriet Hill, Max Crispin, Zania Stamataki, Adam F Cunningham, Matthew Pugh, Abdullah O Khan, Julie Rayes, Maria Vedunova, Dmitri V Krysko, Alexander Brill. Frontiers in immunology. 2022 October;13:968981. [Full Text Article] [PubMed:36225927] [PMC:PMC9548604]

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
CPA3 (8)
No (8)
GST (1)
GST, N-terminus (1)
His (2)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (6)
Mouse (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Yeast (1)
Purified (1)
CPA3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CPA3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
48.71 kDa
20 µg/$150
CPA3 Protein - Recombinant Carboxypeptidase A3, Mast Cell By SDS-PAGE
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E. coli
His-GST
68.4 kDa
10 µg/$283; 50 µg/$457; 100 µg/$732; 200 µg/$912; 1 mg/$2,032; 500 µg/$1,567; 5 mg/$3,193; 2 mg/$2,219
CPA3 Protein
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Yeast
His
38 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
CPA3 Protein - Recombinant Carboxypeptidase A3, Mast Cell By SDS-PAGE
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E. coli
His-T7
50.7 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
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E. coli
His
40.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CPA3 Protein - 12.5% SDS-PAGE of human CPA3 stained with Coomassie Blue
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Wheat Germ Extract
GST
75.1 kDa
2 µg/$439
CPA3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
48.71 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).