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COX6A2

cytochrome c oxidase subunit VIa polypeptide 2

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity.

Gene Name: cytochrome c oxidase subunit VIa polypeptide 2
Synonyms: COX6A2, COX6A, COX6AH, COXVIAH, COX VIa-M
Target Sequences: NM_005205 NP_005196.1 Q02221

Publications (1)

1
COX6A2 variants cause a muscle-specific cytochrome c oxidase deficiency. Michio Inoue, Shumpei Uchino, Aritoshi Iida, Satoru Noguchi, Shinichiro Hayashi, Tsutomu Takahashi, Katsunori Fujii, Hirofumi Komaki, Eri Takeshita, Ikuya Nonaka, Yukinori Okada, Takuya Yoshizawa, Leentje Van Lommel, Frans Schuit, Yu-Ichi Goto, Masakazu Mimaki, Ichizo Nishino. Annals of neurology. 2019 August;86:193-202. [Full Text Article] [PubMed:31155743] Related Antibodies: LS-C166966.

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COX6A2 (3)
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COX6A2 Protein - Purified recombinant protein COX6A2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
9.4 kDa
20 µg/$1,107
COX6A2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
10.82 kDa
100 µg/$494
COX6A2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
10.82 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).