COPS8 / COP9

COP9 signalosome subunit 8

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

COPS8 / COP9 (8)

Publications

No (8)

Tag

GST (1)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (2)

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COPS8 / COP9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115133

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23 kDa

Price:

100 µg/$494

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COPS8 / COP9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103737

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.7 kDa

Price:

100 µg/$494

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Human COPS8 / COP9 Protein (Recombinant His, N-Terminal) - LS-G143987

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

23.2 kDa

Price:

50 µg/$419

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Human COPS8 / COP9 Protein (Recombinant GST) (Full Length) - LS-G32393

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

48.73 kDa

Price:

10 µg/$479; 25 µg/$670

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Human COPS8 / COP9 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68190

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.7 kDa

Price:

20 µg/$1,107

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Human COPS8 / COP9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81624

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.7 kDa

Price:

20 µg/$150

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Human COPS8 / COP9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81626

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23 kDa

Price:

20 µg/$150

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Human COPS8 / COP9 Protein (Recombinant His) - LS-G1496

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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