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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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COPS8 / COP9

COP9 signalosome subunit 8

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Name: COP9 signalosome subunit 8
Synonyms: COPS8, COP9 homolog, CSN8, HCOP9, SGN8, COP9, MMMEP, Signalosome subunit 8
Target Sequences: NM_006710 NP_006701.1 Q99627

Filtered By: None
Target
COPS8 / COP9 (28)
Reactivity
Human (28)
Mouse (6)
Rat (7)
Bovine (4)
Chimpanzee (3)
Gibbon (3)
Guinea pig (4)
Hamster (4)
Horse (4)
Monkey (4)
Orangutan (3)
Rabbit (4)
Application
IHC (3)
IHC-P (2)
WB (24)
ELISA (16)
IF (1)
Host
rabbit (20)
mouse (8)
Isotype
IgG (16)
IgG2a,k (7)
Clonality
monoclonal mc (7)
polyclonal pc (21)
Format
AP Conjugated (2)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (10)
Epitope
aa1-30 (8)
C-Terminus (5)
Publications
No (28)
Showing 1-25 of 28 results

COPS8 / COP9 Antibody (C-Terminus) IHC-plus™ LS-B4592
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-COPS8 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-COPS8 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-COPS8 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-COPS8 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

COPS8 / COP9 Antibody LS-C664714
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Human
ELISA IHC WB
Unconjugated
100µg  $335.00

COPS8 / COP9 Antibody LS-C671988
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Human
ELISA IHC IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry image at a dilution of 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system.
Immunohistochemistry image at a dilution of 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system.

COPS8 / COP9 Antibody LS-C307815
Mouse Monoclonal (IgG2a,k) to Human COPS8 / COP9
Human
ELISA WB
Unconjugated
100µg  $560.00

COPS8 / COP9 Antibody (HRP) LS-C541571
Mouse Monoclonal (IgG2a,k) to Human COPS8 / COP9
Human
ELISA WB
HRP Conjugated
100µl  $710.00

COPS8 / COP9 Antibody (Biotin) LS-C521439
Mouse Monoclonal (IgG2a,k) to Human COPS8 / COP9
Human
ELISA WB
Biotin Conjugated
100µl  $710.00

COPS8 / COP9 Antibody (FITC) LS-C531483
Mouse Monoclonal (IgG2a,k) to Human COPS8 / COP9
Human
ELISA WB
FITC Conjugated
100µl  $710.00

COPS8 / COP9 Antibody (PE) LS-C649683
Mouse Monoclonal (IgG2a,k) to Human COPS8 / COP9
Human
ELISA WB
PE Conjugated
100µl  $710.00

COPS8 / COP9 Antibody (APC) LS-C513224
Mouse Monoclonal (IgG2a,k) to Human COPS8 / COP9
Human
ELISA WB
APC Conjugated
100µl  $710.00

COPS8 / COP9 Antibody (AP) LS-C503515
Mouse Monoclonal (IgG2a,k) to Human COPS8 / COP9
Human
ELISA WB
AP Conjugated
100µl  $710.00

COPS8 / COP9 Antibody (aa1-30) LS-C320525
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Human
ELISA WB
Unconjugated
200µl  $530.00

COPS8 / COP9 Antibody (aa1-30, Biotin) LS-C213397
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

COPS8 / COP9 Antibody (aa1-30, FITC) LS-C213399
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Human
ELISA WB
FITC Conjugated
200µl  $680.00

COPS8 / COP9 Antibody (aa1-30, Azide-free, HRP) LS-C213398
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

COPS8 / COP9 Antibody (aa1-30, AP) LS-C213395
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Human
ELISA WB
AP Conjugated
200µl  $680.00

COPS8 / COP9 Antibody (aa1-30, APC) LS-C213396
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Human
ELISA WB
APC Conjugated
200µl  $680.00

COPS8 / COP9 Antibody (aa1-30, PE) LS-C213400
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Human
ELISA WB
PE Conjugated
200µl  $680.00

COPS8 / COP9 Antibody LS-C307816
Mouse Polyclonal (IgG) to Human COPS8 / COP9
Rat, Human
IF WB
Unconjugated
50µg  $560.00

COPS8 / COP9 Antibody LS-C410145
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Human
WB
Unconjugated
100µl  $295.00; 200µl  $385.00

COPS8 / COP9 Antibody LS-C747824
Rabbit Polyclonal (IgG) to Human COPS8 / COP9
Mouse, Rat, Human
WB
Unconjugated
50µl  $235.00
Western blot analysis of extracts of various cell lines, using COPS8 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 60s.
Western blot analysis of extracts of various cell lines, using COPS8 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 60s.

COPS8 / COP9 Antibody (C-Terminus) LS-C116463
Rabbit Polyclonal to Human COPS8 / COP9
Rabbit, Mouse, Guinea pig, Bovine, Rat, Hamster, Horse, Human, Monkey
WB
Unconjugated
50µg  $365.00
COPS8 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
COPS8 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS8 / COP9 Antibody (C-Terminus, HRP) LS-C455749
Rabbit Polyclonal to Human COPS8 / COP9
Rabbit, Mouse, Guinea pig, Bovine, Rat, Hamster, Horse, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
COPS8 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
COPS8 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS8 / COP9 Antibody (C-Terminus, Biotin) LS-C455746
Rabbit Polyclonal to Human COPS8 / COP9
Rabbit, Mouse, Guinea pig, Bovine, Rat, Hamster, Horse, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
COPS8 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
COPS8 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS8 / COP9 Antibody (C-Terminus, FITC) LS-C455747
Rabbit Polyclonal to Human COPS8 / COP9
Rabbit, Mouse, Guinea pig, Bovine, Rat, Hamster, Horse, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100µl 1mg/ml  $385.00
COPS8 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
COPS8 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS8 / COP9 Antibody (aa1-30) LS-C166946
Rabbit Polyclonal to Human COPS8 / COP9
Human
WB
Unconjugated
400µl  $305.00
COPS8 Antibody western blot of Ramos cell line lysates (35 ug/lane). The COPS8 antibody detected the COPS8 protein (arrow).
COPS8 Antibody western blot of Ramos cell line lysates (35 ug/lane). The COPS8 antibody detected the COPS8 protein (arrow).
Showing 1-25 of 28 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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