Products
Research Areas
COVID-19
Resources
Contact Us
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Cart
How To Buy
Contact Us

Locations

Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464

Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers


Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us


Additional Contact Details

Distributors
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

COPS6 / CSN6

COP9 signalosome subunit 6

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets.

Gene Name: COP9 signalosome subunit 6
Synonyms: COPS6, CSN6, H_NH0506M12.12, MOV34 homolog, 34 kD, MOV34 homolog, MOV34-34KD, Vpr-interacting protein, SGN6, Signalosome subunit 6, HVIP
Target Sequences: NM_006833 NP_006824.2 Q7L5N1

Publications (1)

1
Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. Yang L, Liu Y, Wang M, Qian Y, Dong X, Gu H, Wang H, Guo S, Hisamitsu T. Molecular medicine reports. 2016 14:4559-4566. (WB; Human) [Full Text Article] [PubMed:27748879] [PMC:PMC5101998] Related Antibodies: LS-C174568.

☰ Filters
Products
Antibodies (18)
Primary (18)
COPS6 / CSN6 (18)
Human (18)
Mouse (4)
Rat (4)
Bat (3)
Bovine (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (3)
Orangutan (3)
Pig (3)
Rabbit (3)
Xenopus (3)
IHC (9)
IHC-P (7)
WB (17)
ELISA (1)
ICC (1)
IF (4)
rabbit (11)
mouse (7)
Product Group
IHCPlus (1)
IgG (1)
IgG1 (4)
IgG2a (2)
IgG2a,k (1)
monoclonal mc (7)
polyclonal pc (11)
2H5 (1)
OTI2F5 (2)
OTI2H4 (2)
OTI4E7 (2)
Biotin Conjugated (2)
Carrier-free (3)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (12)
C-Terminus (4)
aa201-250 (4)
aa58-327 (4)
No (17)
Yes (1)
COPS6 / CSN6 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-COPS6 mouse monoclonal antibody.
Select
COPS6 / CSN6 Antibody (clone OTI4E7) LS-C174568
(4.0) Rating
(1) Publication(s)
COPS6 / CSN6 Mouse anti-Human Monoclonal (OTI4E7) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
COPS6 / CSN6 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-COPS6 mouse monoclonal antibody.
Select
COPS6 / CSN6 Antibody (aa58-327, clone OTI4E7, Carrier-free) LS-C787915
COPS6 / CSN6 Mouse anti-Human Monoclonal (aa58-327) (Carrier-free) (OTI4E7) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
COPS6 / CSN6 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
COPS6 / CSN6 Antibody (aa201-250) LS-B12649
COPS6 / CSN6 Rabbit anti-Human Polyclonal (aa201-250) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
COPS6 / CSN6 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
COPS6 / CSN6 Antibody (aa201-250, HRP) LS-C466170
COPS6 / CSN6 Rabbit anti-Human Polyclonal (aa201-250) (HRP) Antibody
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon, Orangutan
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
COPS6 / CSN6 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
COPS6 / CSN6 Antibody (aa201-250, Biotin) LS-C466168
COPS6 / CSN6 Rabbit anti-Human Polyclonal (aa201-250) (Biotin) Antibody
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon, Orangutan
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
COPS6 / CSN6 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
COPS6 / CSN6 Antibody (aa201-250, FITC) LS-C466169
COPS6 / CSN6 Rabbit anti-Human Polyclonal (aa201-250) (FITC) Antibody
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon, Orangutan
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
COPS6 / CSN6 Antibody
Select
COPS6 / CSN6 Antibody LS-C668262
COPS6 / CSN6 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321
COPS6 / CSN6 Antibody - Immunoperoxidase of monoclonal antibody to COPS6 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 1.5 ug/ml]
Select
COPS6 / CSN6 Antibody (clone 2H5) LS-C134034
COPS6 / CSN6 Mouse anti-Human Monoclonal (2H5) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µg/$423
COPS6 / CSN6 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-COPS6 mouse monoclonal antibody.
Select
COPS6 / CSN6 Antibody (clone OTI2F5) LS-C174502
COPS6 / CSN6 Mouse anti-Human Monoclonal (OTI2F5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
COPS6 / CSN6 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-COPS6 mouse monoclonal antibody.
Select
COPS6 / CSN6 Antibody (aa58-327, clone OTI2F5, Carrier-free) LS-C797651
COPS6 / CSN6 Mouse anti-Human Monoclonal (aa58-327) (Carrier-free) (OTI2F5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
COPS6 / CSN6 Antibody - Immunofluorescence analysis of A549 cells.
Select
COPS6 / CSN6 Antibody LS-C346213
COPS6 / CSN6 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
COPS6 / CSN6 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY COPS6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-COPS6.
Select
COPS6 / CSN6 Antibody (aa58-327, clone OTI2H4) LS-C340612
COPS6 / CSN6 Mouse anti-Human Monoclonal (aa58-327) (OTI2H4) Antibody
Human
WB
Unconjugated
100 µl/$434
COPS6 / CSN6 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY COPS6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-COPS6.
Select
COPS6 / CSN6 Antibody (aa58-327, clone OTI2H4, Carrier-free) LS-C797653
COPS6 / CSN6 Mouse anti-Human Monoclonal (aa58-327) (Carrier-free) (OTI2H4) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
COPS6 / CSN6 Antibody - Western blot: Luminograph of a HeLa S3 cytosol preparation after SDS PAGE followed by blotting onto PVDF membrane and probing with (a) antibody BML-PW8295 and (b) antibody BML-PW8295 pre-absorbed with cognate peptide.
Select
COPS6 / CSN6 Antibody LS-C343788
COPS6 / CSN6 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$553
COPS6 / CSN6 Antibody - Western blot of COPS6 Antibody with human Fetal Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
COPS6 / CSN6 Antibody (C-Terminus) LS-C345570
COPS6 / CSN6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
COPS6 / CSN6 Antibody - Western blot of COPS6 Antibody with human Fetal Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
COPS6 / CSN6 Antibody (C-Terminus, HRP) LS-C466167
COPS6 / CSN6 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
COPS6 / CSN6 Antibody - Western blot of COPS6 Antibody with human Fetal Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
COPS6 / CSN6 Antibody (C-Terminus, Biotin) LS-C466165
COPS6 / CSN6 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
COPS6 / CSN6 Antibody - Western blot of COPS6 Antibody with human Fetal Lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
COPS6 / CSN6 Antibody (C-Terminus, FITC) LS-C466166
COPS6 / CSN6 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
Viewing 1-18 of 18 product results

(0) Selected Add Selected To Cart Compare Selected Clear Selected Top Of Search
Filtered By:
Products: Antibodies


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

Family of Companies
Site Links Home All Antibodies How To Buy All Proteins Distributors All ELISA & Assay Kits Reviews PathPlus™ Antibodies
Follow LSBio View Cart Register or Login
Copyright © 2022 LifeSpan BioSciences, Inc - Privacy Policy
Contact Us

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464

Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

To place an order:
Orders@LSBio.com

For questions about orders:
Customer.Support@LSBio.com

For technical assistance:
Technical.Support@LSBio.com