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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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COPS6 / CSN6

COP9 signalosome subunit 6

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets.

Gene Name: COP9 signalosome subunit 6
Synonyms: COPS6, CSN6, H_NH0506M12.12, MOV34 homolog, 34 kD, MOV34 homolog, MOV34-34KD, Vpr-interacting protein, SGN6, Signalosome subunit 6, HVIP
Target Sequences: NM_006833 NP_006824.2 Q7L5N1

Publications (1)

1
Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. Yang L, Liu Y, Wang M, Qian Y, Dong X, Gu H, Wang H, Guo S, Hisamitsu T. Molecular medicine reports. 2016 14:4559-4566. (WB; Human) [Full Text Article] [PubMed:27748879] [PMC:PMC5101998] Related Antibodies: LS-C174568.

Filtered By: None
Target
COPS6 / CSN6 (16)
Reactivity
Human (16)
Mouse (6)
Rat (6)
Bat (4)
Bovine (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Horse (4)
Monkey (4)
Orangutan (3)
Pig (4)
Rabbit (4)
Xenopus (4)
Application
IHC (8)
IHC-P (7)
WB (15)
ELISA (1)
ICC (1)
IF (4)
Host
rabbit (12)
mouse (4)
Isotype
IgG (1)
IgG1 (2)
IgG2a (1)
IgG2a,k (1)
Clonality
monoclonal mc (4)
polyclonal pc (12)
Clone
2F5 (1)
2H4 (1)
2H5 (1)
4E7 (1)
Format
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (10)
Epitope
C-Terminus (4)
aa201-250 (4)
aa58-327 (1)
Publications
No (15)
Yes (1)
Showing 1-16 of 16 results

COPS6 / CSN6 Antibody (aa201-250) IHC-plus™ LS-B12649
Rabbit Polyclonal to Human COPS6 / CSN6
Xenopus, Bat, Rat, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey
IHC IHC-P WB
Unconjugated
50µg  $485.00
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-COPS6 antibody western blot of 721_B cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-COPS6 antibody western blot of 721_B cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS6 / CSN6 Antibody (aa201-250, HRP) LS-C466170
Rabbit Polyclonal to Human COPS6 / CSN6
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon, Orangutan
IHC IHC-P WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-COPS6 antibody western blot of 721_B cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-COPS6 antibody western blot of 721_B cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS6 / CSN6 Antibody (aa201-250, Biotin) LS-C466168
Rabbit Polyclonal to Human COPS6 / CSN6
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon, Orangutan
IHC IHC-P WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-COPS6 antibody western blot of 721_B cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-COPS6 antibody western blot of 721_B cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS6 / CSN6 Antibody (aa201-250, FITC) LS-C466169
Rabbit Polyclonal to Human COPS6 / CSN6
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon, Orangutan
IHC IHC-P WB
FITC Conjugated
100µl 1mg/ml  $385.00
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-COPS6 antibody western blot of 721_B cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-COPS6 antibody western blot of 721_B cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS6 / CSN6 Antibody (clone 4E7) LS-C174568
Publications (1)
Publications (1)
Mouse Monoclonal [clone 4E7] (IgG2a) to Human COPS6 / CSN6
Human
IF IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $335.00
IHC of paraffin-embedded Human Kidney tissue using anti-COPS6 mouse monoclonal antibody.
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-COPS6 mouse monoclonal antibody.
IHC of paraffin-embedded Human Kidney tissue using anti-COPS6 mouse monoclonal antibody.
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-COPS6 mouse monoclonal antibody.

COPS6 / CSN6 Antibody LS-C412705
Rabbit Polyclonal to Human COPS6 / CSN6
Mouse, Rat, Human
IF IHC WB
Unconjugated
100µl  $385.00

COPS6 / CSN6 Antibody LS-C668262
Rabbit Polyclonal to Human COPS6 / CSN6
Human
ICC IF WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Immunofluorescence Image
Western blot Image
Immunofluorescence Image
Western blot Image

COPS6 / CSN6 Antibody (clone 2H5) LS-C134034
Mouse Monoclonal [clone 2H5] (IgG2a,k) to Human COPS6 / CSN6
Human
ELISA IHC IHC-P
Unconjugated
100µg  $355.00
Immunoperoxidase of monoclonal antibody to COPS6 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 1.5 ug/ml]
Immunoperoxidase of monoclonal antibody to COPS6 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 1.5 ug/ml]

COPS6 / CSN6 Antibody (clone 2F5) LS-C174502
Mouse Monoclonal [clone 2F5] (IgG1) to Human COPS6 / CSN6
Human
IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-COPS6 mouse monoclonal antibody.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY COPS6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-COPS6.
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-COPS6 mouse monoclonal antibody.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY COPS6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-COPS6.

COPS6 / CSN6 Antibody LS-C346213
Rabbit Polyclonal (IgG) to Human COPS6 / CSN6
Mouse, Rat, Human
IF WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunofluorescence analysis of A549 cells.
Western blot analysis of extracts of various cell lines.
Immunofluorescence analysis of A549 cells.
Western blot analysis of extracts of various cell lines.

COPS6 / CSN6 Antibody (aa58-327, clone 2H4) LS-C340612
Mouse Monoclonal [clone 2H4] (IgG1) to Human COPS6 / CSN6
Human
WB
Unconjugated
100µl 1mg/ml  $335.00
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY COPS6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-COPS6.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY COPS6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-COPS6.

COPS6 / CSN6 Antibody (C-Terminus) LS-C345570
Rabbit Polyclonal to Human COPS6 / CSN6
Human
WB
Unconjugated
50µg  $365.00
Western blot of COPS6 Antibody with human Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of COPS6 Antibody with human Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS6 / CSN6 Antibody (C-Terminus, HRP) LS-C466167
Rabbit Polyclonal to Human COPS6 / CSN6
Human
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Western blot of COPS6 Antibody with human Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of COPS6 Antibody with human Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS6 / CSN6 Antibody (C-Terminus, Biotin) LS-C466165
Rabbit Polyclonal to Human COPS6 / CSN6
Human
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Western blot of COPS6 Antibody with human Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of COPS6 Antibody with human Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS6 / CSN6 Antibody (C-Terminus, FITC) LS-C466166
Rabbit Polyclonal to Human COPS6 / CSN6
Human
WB
FITC Conjugated
100µl 1mg/ml  $385.00
Western blot of COPS6 Antibody with human Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of COPS6 Antibody with human Fetal Lung lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

COPS6 / CSN6 Antibody LS-C343788
Rabbit Polyclonal to Human COPS6 / CSN6
Human
WB
Unconjugated
100µl  $425.00
Western blot: Luminograph of a HeLa S3 cytosol preparation after SDS PAGE followed by blotting onto PVDF membrane and probing with (a) antibody BML-PW8295 and (b) antibody BML-PW8295 pre-absorbed with cognate peptide.
Western blot: Luminograph of a HeLa S3 cytosol preparation after SDS PAGE followed by blotting onto PVDF membrane and probing with (a) antibody BML-PW8295 and (b) antibody BML-PW8295 pre-absorbed with cognate peptide.
Showing 1-16 of 16 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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