COPS2 / TRIP15 / ALIEN

COP9 signalosome subunit 2

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

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Products

Proteins (12)

Type

Over-Expression Lysate (4)

Recombinant (8)

Target

COPS2 / TRIP15 / ALIEN (12)

Publications

No (12)

Tag

10His, N-terminus (1)

6His, N-terminus (2)

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (8)

Zebrafish (2)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Yeast (2)

Purification

Purified (6)

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Human COPS2 / TRIP15 / ALIEN Protein (Recombinant GST, N-terminus) (aa344-443) - LS-G61066

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human COPS2 / TRIP15 / ALIEN Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67123

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.4 kDa

Price:

20 µg/$1,107

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Human COPS2 / TRIP15 / ALIEN Protein (Recombinant 6His-SUMO, N-terminus) (aa1-443) - LS-G56788

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human COPS2 / TRIP15 / ALIEN Protein (Recombinant) (aa1-443) - LS-G56789

Source:

E. coli

Tag:

None

Price:

1 mg/$1,756; 100 µg/$611; 20 µg/$447

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Zebrafish COPS2 / TRIP15 / ALIEN Protein (Recombinant 10His, N-terminus) (aa1-443) - LS-G56790

Source:

E. coli

Tag:

10His, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Human COPS2 / TRIP15 / ALIEN Protein (Recombinant 6His, N-terminus) (aa1-443) - LS-G57323

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Zebrafish COPS2 / TRIP15 / ALIEN Protein (Recombinant 6His, N-terminus) (aa1-443) - LS-G57322

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$679; 20 µg/$429; 1 mg/$1,973

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Human COPS2 / TRIP15 / ALIEN Protein (Recombinant GST) (Full Length) - LS-G31577

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78 kDa

Price:

10 µg/$479; 25 µg/$670

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COPS2 / TRIP15 / ALIEN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100240

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.4 kDa

Price:

100 µg/$494

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COPS2 / TRIP15 / ALIEN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126229

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.2 kDa

Price:

100 µg/$494

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Human COPS2 / TRIP15 / ALIEN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79176

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.2 kDa

Price:

20 µg/$150

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Human COPS2 / TRIP15 / ALIEN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79177

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.4 kDa

Price:

20 µg/$150

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