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COPA / Xenin
coatomer protein complex, subunit alpha
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
| Gene Name: | coatomer protein complex, subunit alpha |
| Synonyms: | COPA, Alpha coat protein, Alpha-COP, Alpha COP I, Alpha-coat protein, Coatomer alpha subunit, Coatomer subunit alpha, HEPCOP, HEP-COP, Xenin |
| Target Sequences: | NM_004371 NP_004362.2 P53621 |
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