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COMT

catechol-O-methyltransferase

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Gene Name: catechol-O-methyltransferase
Synonyms: COMT, Catechol O-methyltransferase, Catechol-O-methyltransferase
Target Sequences: NM_007310 NP_009294.1 P21964

Publications (2)

1
Effects and Mechanisms of Radiofrequency Ablation of Renal Sympathetic Nerve on Anti-Hypertension in Canine. Chen W, Tang X, Yang X, Weng C, Yang K, Wen J, Liu H, Wu Y. Arquivos brasileiros de cardiologia. 2017 108:237-245. (WB; Human) [Full Text Article] [PubMed:28273198] [PMC:PMC5389873] Related Antibodies: LS-B4343.
2
Neuronal-enriched extracellular vesicles in individuals with IBS: A pilot study of COMT and BDNF. Kristen R Weaver, Maja Mustapic, Dimitrios Kapogiannis, Wendy A Henderson. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2022 Janurary;34:e14257. [Full Text Article] [PubMed:34499398] [PMC:PMC9358931]

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Products
Antibodies (70)
Primary (70)
COMT (70)
Human (52)
Mouse (28)
Rat (16)
Bat (1)
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Chimpanzee (3)
Dog (3)
Gibbon (3)
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IHC (17)
IHC-P (11)
WB (64)
Flo (1)
ELISA (9)
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IP (3)
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rabbit (64)
mouse (3)
goat (3)
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IHCPlus (8)
IgG (28)
IgG1 (1)
IgG2b,k (1)
monoclonal mc (2)
polyclonal pc (68)
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aa170-183 (1)
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COMT Antibody - Anti-COMT antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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COMT Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
COMT Antibody - Anti-COMT antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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COMT Goat anti-Human Polyclonal (aa170-183) Antibody
Bovine, Pig, Horse, Human, Monkey
ELISA, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
COMT Antibody - Anti-COMT antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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COMT Goat anti-Human Polyclonal (aa52-65) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
COMT Antibody - Anti-COMT antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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COMT Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Rat, Pig, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
COMT Antibody - Anti-COMT antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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COMT Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
COMT Antibody - Immunofluorescent analysis of COMT staining in Raw264.7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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COMT Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, WB
Unconjugated
100 µl/$299
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COMT Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
COMT Antibody - COMT antibody IHC-paraffin. IHC(P): Mouse Lung Tissue.
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COMT Rabbit anti-Human Polyclonal (aa52-271) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
COMT Antibody
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COMT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$575
COMT Antibody - Immunohistochemistry of paraffin-embedded rat kidney tissue.
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COMT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
COMT Antibody - Anti-COMT antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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COMT Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
COMT Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer tissue  using COMT Polyclonal Antibody at dilution of 1:30(×200)
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COMT Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
COMT Antibody - Human, Prostate: Formalin-Fixed Parafin-Embedded (FFPE)
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COMT Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
COMT Antibody - Anti-COMT antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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COMT Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
COMT Antibody - COMT antibody. IHC(P): Human Kidney Cancer Tissue.
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COMT Rabbit anti-Human Polyclonal (aa94-108) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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COMT Rabbit anti-Human Polyclonal (30-110 aa, Internal) Antibody
Human
ELISA, ICC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
COMT Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer tissue  using COMT Polyclonal Antibody at dilution of 1:25(×200)
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COMT Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
COMT Antibody - Detection of Human COMT by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-COMT used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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COMT Rabbit anti-Human Polyclonal (aa221-271) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
COMT Antibody - COMT monoclonal antibody (M01), clone 1G4-1A1 Western Blot analysis of COMT expression in A-431.
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COMT Mouse anti-Human Monoclonal (1G4-1A1) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
COMT Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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COMT Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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COMT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$346; 100 µl/$443
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COMT Rabbit anti-Human Polyclonal (aa111-156) Antibody
Mouse, Rat, Human
ICC, WB
Unconjugated
50 µl/$321; 100 µl/$403
COMT Antibody - Western blot analysis of COMT using anti-COMT antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: mouse liver tissue lysates,Lane 2: mouse stomach tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-COMT antigen affinity purified polyclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for COMT at approximately 25 and 29KD. The expected band size for COMT is at 29KD.
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COMT Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
COMT Antibody - Western blot testing of 1) mouse liver and 2) mouse stomach lysate with COMT antibody at 0.5ug//ml. Predicted molecular weight: ~30/25 kDa (isoforms 1/2).
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COMT Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$575
COMT Antibody - Western blot analysis of extracts from HepG2 cells and HUVEC cells, using COMT antibody.
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COMT Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).