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Complement C4b

complement component 4B (Chido blood group)

Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Gene Name: complement component 4B (Chido blood group)
Synonyms: C4B, C4B12, C4BD, C4B1, C4B3, Complement C4B, CH, Chido form of C4, CPAMD3, Complement C4-B, CO4, Basic complement C4, C4B2, C4B5, C4F, Complement C4B1a, Complement component 4B
Target Sequences: U24578 AAA99717.1

Publications (1)

1
Inhaled diesel exhaust alters the allergen-induced bronchial secretome in humans. Neeloffer Mookherjee, Hadeesha Piyadasa, Min Hyung Ryu, Christopher Francis Rider, Peyman Ezzati, Victor Spicer, Christopher Carlsten. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2018 Jan;51:1701385. [Full Text Article] [PubMed:29371381]

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Antibodies (42)
Primary (42)
Complement C4b (42)
Human (28)
Mouse (17)
Horse (3)
Monkey (3)
Orangutan (3)
IHC (6)
IHC-P (6)
WB (30)
Flo (1)
ELISA (12)
rabbit (38)
mouse (3)
chicken (1)
Product Group
IHCPlus (2)
IgG (10)
IgG2a (2)
IgG2b,k (1)
IgY (1)
monoclonal mc (3)
polyclonal pc (39)
2E3 (1)
OTI1B2 (2)
APC (3)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (6)
Carrier-free (1)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (4)
Unconjugated (10)
aa678-753 (8)
aa680-756 (8)
aa655-684 (6)
aa144-193 (4)
aa1454-1744 (4)
aa1100-1350 (2)
No (42)
Complement C4b Antibody - Anti-C4B antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Complement C4b Chicken anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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Complement C4b Rabbit anti-Mouse Polyclonal (aa655-684) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
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Complement C4b Rabbit anti-Mouse Polyclonal (aa655-684) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
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Complement C4b Rabbit anti-Mouse Polyclonal (aa655-684) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
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Complement C4b Rabbit anti-Mouse Polyclonal (aa655-684) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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Complement C4b Rabbit anti-Mouse Polyclonal (aa655-684) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
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Complement C4b Rabbit anti-Mouse Polyclonal (aa655-684) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
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Complement C4b Rabbit anti-Mouse Polyclonal (aa678-753) Antibody
Mouse
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
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Complement C4b Rabbit anti-Mouse Polyclonal (aa678-753) (HRP) Antibody
Mouse
HRP Conjugated
100 µl/$335; 200 µl/$389; 500 µl/$566; 1 ml/$685; 2 ml/$922; 5 ml/$1,557
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Complement C4b Rabbit anti-Mouse Polyclonal (aa678-753) (Biotin) Antibody
Mouse
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
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Complement C4b Rabbit anti-Mouse Polyclonal (aa678-753) (FITC) Antibody
Mouse
FITC Conjugated
100 µl/$345; 200 µl/$402; 500 µl/$594; 1 ml/$737; 2 ml/$976; 5 ml/$1,676
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Complement C4b Rabbit anti-Mouse Polyclonal (aa678-753) (APC) Antibody
Mouse
APC Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
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Complement C4b Rabbit anti-Mouse Polyclonal (aa678-753) (APC, Cy7) Antibody
Mouse
APC, Cy7 Conjugated
100 µl/$497; 200 µl/$632; 500 µl/$1,132; 1 ml/$1,369; 2 ml/$1,916; 5 ml/$3,592
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Complement C4b Rabbit anti-Mouse Polyclonal (aa678-753) (Cy3) Antibody
Mouse
Cy3 Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
Complement C4b Antibody - Detection limit for recombinant GST tagged C4B is approximately 0.1 ng/ml as a capture antibody.
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Complement C4b Mouse anti-Human Monoclonal (2E3) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Complement C4b Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Complement C4b Rabbit anti-Human Polyclonal (aa1454-1744) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Complement C4b Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Complement C4b Rabbit anti-Human Polyclonal (aa1454-1744) (HRP) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$294; 100 µg/$360
Complement C4b Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Complement C4b Rabbit anti-Human Polyclonal (aa1454-1744) (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
Complement C4b Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Complement C4b Rabbit anti-Human Polyclonal (aa1454-1744) (FITC) Antibody
Human
ELISA, IHC, IHC-P
FITC Conjugated
50 µg/$294; 100 µg/$360
Complement C4b Antibody - Human Small Intestine, Vessels: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Complement C4b Rabbit anti-Human Polyclonal (aa680-756) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Complement C4b Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY C4B. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-C4B. (1:500)
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Complement C4b Mouse anti-Human Monoclonal (aa1100-1350) (OTI1B2) Antibody
Human
WB
Unconjugated
100 µl/$434
Complement C4b Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY C4B. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-C4B. (1:500)
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Complement C4b Mouse anti-Human Monoclonal (aa1100-1350) (Carrier-free) (OTI1B2) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
Complement C4b Antibody - C4B antibody Western blot of HeLa lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Complement C4b Rabbit anti-Human Polyclonal (aa144-193) Antibody
Human
WB
Unconjugated
100 µl/$424
Complement C4b Antibody - Western Blot; Sample: Recombinant C4d, Human.
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Complement C4b Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$323; 200 µl/$371; 500 µl/$531; 1 ml/$617; 2 ml/$850; 5 ml/$1,401
Complement C4b Antibody - Western Blot; Sample: Recombinant C4d, Human.
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Complement C4b Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$563; 1 ml/$678; 2 ml/$915; 5 ml/$1,541
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).