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Complement C3

complement component 3

C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Gene Name: complement component 3
Synonyms: C3, AHUS5, ARMD9, Complement component C3, CPAMD1, Complement C3, ASP, Complement component 3
Target Sequences: NM_000064 NP_000055.2 P01024

Publications (8)

1
Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia. Wang W, Irani RA, Zhang Y, Ramin SM, Blackwell SC, Tao L, Kellems RE, Xia Y. Hypertension. 2012 60:712-21. (IHC; Mouse) [Full Text Article] [PubMed:22868393] [PMC:PMC4131740] Related Antibodies: LS-C22283.
2
Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites. Braig D, Nero TL, Koch HG, Kaiser B, Wang X, Thiele JR, Morton CJ, Zeller J, Kiefer J, Potempa LA, Mellett NA, Miles LA, Du XJ, Meikle PJ, Huber-Lang M, Stark GB, Parker MW, Peter K, Eisenhardt SU. Nature communications. 2017 8:14188. (Flo; Human) [Full Text Article] [PubMed:28112148] [PMC:PMC5264208] Related Antibodies: LS-C62856.
3
Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases. Fridkis-Hareli M, Storek M, Mazsaroff I, Risitano AM, Lundberg AS, Horvath CJ, Holers VM. Blood. 2011 118:4705-13. (Flo; Human) [Full Text Article] [PubMed:21860027] Related Antibodies: LS-C34556.
4
Involvement of complement activation in the pulmonary vasoactivity of polystyrene nanoparticles in pigs: unique surface properties underlying alternative pathway activation and instant opsonization. Tamás Mészáros, Gergely Tibor Kozma, Taro Shimizu, Koga Miyahara, Keren Turjeman, Tatsuhiro Ishida, Yechezkel Barenholz, Rudolf Urbanics, János Szebeni. International journal of nanomedicine. 2018 October;13:6345-6357. [Full Text Article] [PubMed:30349254] [PMC:PMC6187999] Related Antibodies: LS-C209615.
5
Clinical study and assessment of leukocyte phagocytic function in children with atopic dermatitis in Qassim region of Saudi Arabia. Yasser F Abdullraheem, Abullateef A Alzolibani, Khaleed H Mahmoud, Amani H Korsni, Muhmmad Helyel Al-Harbi, Kaleed M Hassanin, Mohammed S Al-Dhubaibi. International journal of health sciences. 2017 November;11:44015. [PubMed:29085260] [PMC:PMC5654183]
6
Seasonal heat load is more potent than the degree of body weight loss in dysregulating immune function by reducing white blood cell populations and increasing inflammation in Holstein dairy cows. M Zachut, G Kra, N Nemes-Navon, N Ben-Aharon, U Moallem, Y Lavon, S Jacoby. Journal of dairy science. 2020 November;103:10809-10822. [Full Text Article] [PubMed:32896401]
7
Chemotherapy-induced complement signaling modulates immunosuppression and metastatic relapse in breast cancer. Lea Monteran , Nour Ershaid , Hila Doron, Yael Zait, Ye'ela Scharff, Shahar Ben-Yosef, Camila Avivi, Iris Barshack, Amir Sonnenblick, Neta Erez. Nature communications. 2022 October;13:5797. [Full Text Article] [PubMed:36184683] [PMC:PMC9527249] Related Antibodies: LS-B4290.
8
Complement opsonization of nanoparticles: Differences between humans and preclinical species. Yue Li, Guankui Wang, Lynn Griffin, Nirmal K Banda, Laura M Saba, Ernest V Groman, Robert Scheinman, S Moein Moghimi, Dmitri Simberg. Journal of controlled release : official journal of the Controlled Release Society. 2021 October;338:548-556. [Full Text Article] [PubMed:34481928] [PMC:PMC8552414] Related Antibodies: LS-C372631.
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Complement C3 (38)
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Mouse (7)
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Serum (36)
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Complement C3 ELISA Kit
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Sandwich
96-Well Microplate
Human
7.81 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$724
Complement C3 ELISA Kit
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Sandwich
96-Well Microplate
Rat
7.81 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
Complement C3 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
Complement C3 ELISA Kit
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Sandwich
96-Well Microplate
Pig
7.81 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.02 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture, Milk, Plasma, Saliva, Serum, Urine
1 Plate/$690
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.2 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$896
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$537
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
Complement C3 ELISA Kit
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Sandwich
96-Well Microplate
Human
4.7 - 300 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Saliva, Serum, Urine
1 Plate/$782
Complement C3 ELISA Kit
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Sandwich
96-Well Microplate
Human
63 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Complement C3 ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Monkey
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
7.81 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Complement C3 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rabbit
27.3 - 7000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$1,100
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
3.906 - 250 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$598
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$598
Complement C3 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Dog
0.78 - 50 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
Complement C3 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Pig
0.625 - 10 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
Complement C3 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
0.625 - 40 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
Complement C3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
93.75 - 6000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
Complement C3 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).