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COMP / THBS5

cartilage oligomeric matrix protein

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.

Gene Name: cartilage oligomeric matrix protein
Synonyms: COMP, MED, PSACH, Thrombospondin-5, TSP5, THBS5, EDM1, EPD1
Target Sequences: NM_000095 NP_000086.2 P49747

Publications (1)

1
Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer. Junki Harada, Yasuyoshi Miyata, Kyohei Araki, Tsuyoshi Matsuda, Yoshiaki Nagashima, Yuta Mukae, Kensuke Mistunari, Tomohiro Matsuo, Kojiro Ohba, Yasushi Mochizuki, Hideki Sakai. In Vivo. 2021 April;35:1693-1701. [Full Text Article] [PubMed:33910854] [PMC:PMC8193323]

☰ Filters
Antibodies (88)
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COMP / THBS5 (131)
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COMP / THBS5 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
COMP / THBS5 Antibody - Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with COMP Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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COMP / THBS5 Rabbit anti-Human Polyclonal (aa314-343) Antibody
Human
Flo, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
400 µl/$393
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COMP / THBS5 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$657
COMP / THBS5 Antibody - Western blot. All lanes: Cartilage oligomeric matrix protein antibody at 4 ug/ml+mouse skeletal muscle tissue. Secondary antibody: Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 83 kDa. Observed band size: 83 kDa.
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COMP / THBS5 Rabbit anti-Human Polyclonal (aa20-160) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µl/$294; 100 µl/$360
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COMP / THBS5 Rabbit anti-Human Polyclonal (aa20-160) Antibody
Human
ELISA
Unconjugated
50 µl/$294; 100 µl/$360
COMP / THBS5 Antibody - Western blot of COMP Antibody with human 786-0 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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COMP / THBS5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
COMP / THBS5 Antibody - Western blot of COMP Antibody with human 786-0 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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COMP / THBS5 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Mouse, Dog, Rat, Pig, Horse, Human
WB
HRP Conjugated
100 µl/$469
COMP / THBS5 Antibody - Western blot of COMP Antibody with human 786-0 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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COMP / THBS5 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Dog, Rat, Pig, Horse, Human
WB
Biotin Conjugated
100 µl/$469
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$699
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$705
Select
COMP / THBS5 Rabbit anti-Human Polyclonal (aa314-343) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
COMP / THBS5 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr, WB
Unconjugated
100 µg/$657
COMP / THBS5 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using COMP Polyclonal Antibody at dilution of 1:50.
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COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
COMP / THBS5 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
COMP / THBS5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
82.4 kDa
100 µg/$721
Select
COMP / THBS5 Rat anti-Human Monoclonal (MA37C94 (HC484D1)) Antibody
Human
ELISA, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.2 mg/$486
Select
COMP / THBS5 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$657
COMP / THBS5 Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using COMP Polyclonal Antibody at dilution of 1:50.
Select
COMP / THBS5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
COMP / THBS5 Antibody - Western Blot; Sample: Recombinant COMP, Human.
Select
COMP / THBS5 Rabbit anti-Human Polyclonal (aa123-240) Antibody
Pig, Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
COMP / THBS5 Antibody - Western Blot; Sample: Recombinant COMP, Human.
Select
COMP / THBS5 Rabbit anti-Human Polyclonal (aa123-240) (HRP) Antibody
Pig, Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
COMP / THBS5 Antibody - Western Blot; Sample: Recombinant COMP, Human.
Select
COMP / THBS5 Rabbit anti-Human Polyclonal (aa123-240) (Biotin) Antibody
Pig, Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
Viewing 1-25 of 131 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).