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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Collagen I

Type I collagen is the most abundant collagen of the human body which forms large, eosinophilic fibers known as collagen fibers. It is present in scar tissue, the end product when tissue heals by repair, as well as tendons, ligaments, the endomysium of myofibrils, the organic part of bone, the dermis, the dentin and organ capsules. Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is encoded by the COL1A1 gene. Collagen alpha-2(I) chain is encoded by the COL1A2 gene. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for alpha-1 type I collagen since alpha-2 is less abundant. Multiple messages for this gene result from multiple polyadenylation signals, a feature shared by most of the other collagen genes.

Collagen I Target Details

Target Name: Collagen I

Publications (5)

1
Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Stefanovic B, Schnabl B, Brenner DA. The Journal of biological chemistry. 2002 277:18229-37. [PubMed:11889120] Related Antibodies: LS-B342.
2
Bone marrow-derived progenitor cells in pulmonary fibrosis. Hashimoto N, Jin H, Liu T, Chensue SW, Phan SH. The Journal of clinical investigation. 2004 113:243-52. [PubMed:14722616] [PMC:PMC310750] Related Antibodies: LS-B342.
3
Adipogenic transcriptional regulation of hepatic stellate cells. She H, Xiong S, Hazra S, Tsukamoto H. The Journal of biological chemistry. 2005 280:4959-67. [PubMed:15537655] Related Antibodies: LS-B342.
4
Hepatic steatosis, fibrosis, and cancer in elderly cadavers. Mak KM, Kwong AJ, Chu E, Hoo NM. Anatomical record (Hoboken, N.J. : 2007). 2012 295:40-50. [PubMed:22139908] Related Antibodies: LS-B342.
5
The C-C motif chemokine ligands CCL5, CCL11, and CCL24 induce the migration of circulating fibrocytes from patients with severe asthma. Isgrò M, Bianchetti L, Marini MA, Bellini A, Schmidt M, Mattoli S. Mucosal immunology. 2013 6:718-27. (Flo; Human) [Full Text Article] [PubMed:23149666] Related Antibodies: LS-C79516.
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Filtered By: None
Target
Collagen I (152)
Reactivity
Human (98)
Mouse (28)
Rat (24)
Bovine (20)
Cat (2)
Chicken (10)
Deer (1)
Dog (9)
Goat (1)
Goldfish (3)
Hamster (2)
Monkey (1)
Pig (12)
Rabbit (1)
Salmon (3)
Sheep (10)
Sole (2)
Tuna (4)
Application
IHC (134)
IHC-Fr (40)
IHC-P (24)
WB (46)
Flo (6)
DB (12)
ELISA (123)
FLISA (1)
ICC (34)
IF (29)
IHC-Pfa (1)
IP (14)
RIA (50)
Host
rabbit (78)
mouse (45)
goat (29)
Isotype
IgG (74)
IgG1 (29)
IgG1,k (8)
IgG2b (8)
Clonality
monoclonal mc (45)
polyclonal pc (107)
Clone
2A3 (1)
2F2/51 (1)
4F6 (4)
5D8 (1)
COL-1 (1)
NFI/20 (1)
Format
AP Conjugated (12)
APC (1)
APC Conjugated (11)
Biotin Conjugated (22)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (16)
HRP Conjugated (14)
PE Conjugated (13)
Unconjugated (62)
Epitope
C-Terminus (1)
Publications
No (150)
Yes (2)
Showing 1-25 of 152 results

Collagen I Antibody IHC-plus™ LS-B342
Publications (4)
Publications (4)
Rabbit Polyclonal to Human Collagen I
Mouse, Bovine, Rat, Human
ELISA IHC IHC-P IP WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-Collagen I antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B342 concentration 5 ug/ml.
Immunohistochemistry of Collagen I antibody. Tissue: Normal Kidney. Fixation: formalin fixed paraffin embedded. Antigen retrieval: No antigen retrieval was performed. Primary antibody: Collagen I 1:100 4 hours at room temperature Secondary antibody: Peroxidase goat anti-rabbit at 1:10000 for 45 min at RT. Localization: Distal tubules in normal kidney tissue. Note the absence of staining of glomeruli. Staining: antibody as precipitated red signal with a hematoxylin purple nuclear counterstain.
Anti-Collagen I antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B342 concentration 5 ug/ml.
Immunohistochemistry of Collagen I antibody. Tissue: Normal Kidney. Fixation: formalin fixed paraffin embedded. Antigen retrieval: No antigen retrieval was performed. Primary antibody: Collagen I 1:100 4 hours at room temperature Secondary antibody: Peroxidase goat anti-rabbit at 1:10000 for 45 min at RT. Localization: Distal tubules in normal kidney tissue. Note the absence of staining of glomeruli. Staining: antibody as precipitated red signal with a hematoxylin purple nuclear counterstain.

Collagen I Antibody (clone COL-1) IHC-plus™ LS-B6723
Mouse Monoclonal [clone COL-1] (IgG1) to Bovine Collagen I
Rabbit, Bovine, Rat, Pig, Deer, Human
ELISA IF IHC IHC-Fr IHC-P IHC-Pfa
Unconjugated
50µl  $515.00
Anti-Collagen I antibody IHC of human skin, dermal collagen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6723 dilution 1:50.
Anti-Collagen I antibody IHC of human skin, dermal collagen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6723 dilution 1:50.

Collagen I Antibody (C-Terminus) LS-C79516
Publications (1)
Publications (1)
Mouse Monoclonal (IgG1,k) to Human Collagen I
Sheep, Human
ELISA Flo IHC IHC-Fr WB
Unconjugated
100µg 1mg/ml  $665.00

Collagen I Antibody (HRP) LS-C545200
Mouse Monoclonal (IgG1,k) to Human Collagen I
Dog, Sheep, Bovine, Pig, Human
ELISA Flo IHC WB
HRP Conjugated
100µl  $845.00

Collagen I Antibody (Biotin) LS-C525075
Mouse Monoclonal (IgG1,k) to Human Collagen I
Dog, Sheep, Bovine, Pig, Human
ELISA Flo IHC WB
Biotin Conjugated
100µl  $845.00

Collagen I Antibody (FITC) LS-C535094
Mouse Monoclonal (IgG1,k) to Human Collagen I
Dog, Sheep, Bovine, Pig, Human
ELISA Flo IHC WB
FITC Conjugated
100µl  $845.00

Collagen I Antibody (APC) LS-C516060
Mouse Monoclonal (IgG1,k) to Human Collagen I
Dog, Sheep, Bovine, Pig, Human
ELISA Flo IHC WB
APC Conjugated
100µl 0.9mg/ml  $800.00

Collagen I Antibody IHC-plus™ LS-B3653
Rabbit Polyclonal (IgG) to Human Collagen I
Human
ELISA IF IHC IHC-P
Unconjugated
125µl  $425.00
Anti-Collagen I antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3653 dilution 1:100.
Anti-Collagen I antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3653 dilution 1:100.
Anti-Collagen I antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3653 dilution 1:100.
Anti-Collagen I antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3653 dilution 1:100.

Collagen I Antibody (Biotin) IHC-plus™ LS-B209
Rabbit Polyclonal to Human Collagen I
Mouse, Bovine, Rat, Human
ELISA IHC IHC-P IP WB
Biotin Conjugated
100µg 100µl 1mg/ml  $485.00
Anti-Collagen I antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B209 concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-Collagen I Antibody - Western Blot. Western blot analysis is shown using Affinity Purified anti-Collagen I antibody to detect expression of collagen I in Wistar rat hepatic stellate cells (HSC) in control (GFP-transduced) (left lane) and PPARg-transduced cell lysates (right lane). Protein staining shown below each blot depicts equal protein loading. An equal amount of the whole cell protein (100 ug) was separated by SDS-PAGE and electroblotted to nitro-cellulose membranes. Proteins were detected by incubating the membrane with anti-Collagen I antibody at a concentration of 0.2-2 ug/10 ml in TBS (100 mM Tris-HCl, 0.15 M NaCl, pH 7.4) with 5% Non-fat milk. Detection occurred by incubation with a horseradish peroxidase-conjugated secondary antibody at 1 ug/10 ml. Proteins were detected by a chemiluminescent method using the PIERCE ECL kit (Amersham Biosciences). Other detection systems will yield similar results. See Hazra et al. (2004) for additional details. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-Collagen I antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B209 concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-Collagen I Antibody - Western Blot. Western blot analysis is shown using Affinity Purified anti-Collagen I antibody to detect expression of collagen I in Wistar rat hepatic stellate cells (HSC) in control (GFP-transduced) (left lane) and PPARg-transduced cell lysates (right lane). Protein staining shown below each blot depicts equal protein loading. An equal amount of the whole cell protein (100 ug) was separated by SDS-PAGE and electroblotted to nitro-cellulose membranes. Proteins were detected by incubating the membrane with anti-Collagen I antibody at a concentration of 0.2-2 ug/10 ml in TBS (100 mM Tris-HCl, 0.15 M NaCl, pH 7.4) with 5% Non-fat milk. Detection occurred by incubation with a horseradish peroxidase-conjugated secondary antibody at 1 ug/10 ml. Proteins were detected by a chemiluminescent method using the PIERCE ECL kit (Amersham Biosciences). Other detection systems will yield similar results. See Hazra et al. (2004) for additional details. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Collagen I Antibody LS-C41834
Rabbit Polyclonal (IgG) to Mouse Collagen I
Mouse
ELISA IF IHC IHC-Fr IHC-P RIA
Unconjugated
100µl  $445.00

Collagen I Antibody IHC-plus™ LS-B7923
Rabbit Polyclonal (IgG) to Human Collagen I
Human
ELISA IF IHC IHC-Fr IHC-P RIA
Unconjugated
50µl  $425.00
Anti-Collagen I antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7923 dilution 1:100.
Anti-Collagen I antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7923 dilution 1:100.

Collagen I Antibody LS-C79510
Rabbit Polyclonal (IgG) to Mouse Collagen I
ELISA IHC IHC-Fr RIA WB
Unconjugated
100µg 1mg/ml  $695.00

Collagen I Antibody (clone NFI/20) LS-C27160
Mouse Monoclonal [clone NFI/20] (IgG1) to Human Collagen I
Human
DB ELISA IHC IHC-Fr
Unconjugated
100µg 1ml 0.1mg/ml  $345.00

Collagen I Antibody LS-C79497
Rabbit Polyclonal (IgG) to Mouse Collagen I
Mouse
ELISA IF IHC IHC-P RIA
Unconjugated
500µl  $1,290.00

Collagen I Antibody LS-C79490
Rabbit Polyclonal (IgG) to Human Collagen I
Human
ELISA IHC IHC-Fr IP WB
Unconjugated
50µg 0.92mg/ml  $455.00; 100µg  $740.00

Collagen I Antibody LS-C79507
Rabbit Polyclonal (IgG) to Rat Collagen I
Rat
ELISA IF IHC IHC-Fr IHC-P RIA
Unconjugated
500µl  $1,170.00

Collagen I Antibody LS-C121633
Rabbit Polyclonal to Rat Collagen I
Rat
ELISA ICC IHC IHC-Fr
Unconjugated
1000µl 0.1mg/ml  $560.00

Collagen I Antibody (Biotin) LS-C79518
Goat Polyclonal (IgG) to Human Collagen I
Human
ELISA ICC IHC IHC-Fr
Biotin Conjugated
200µg 0.4mg/ml  $860.00

Collagen I Antibody LS-C417690
Rabbit Polyclonal to Human Collagen I
Mouse, Rat, Human
ICC IF IHC WB
Unconjugated
100µg 1mg/ml  $305.00

Collagen I Antibody LS-C121630
Rabbit Polyclonal to Human Collagen I
Human
ELISA IF IHC IHC-Fr WB
Unconjugated
1000µl  $455.00

Collagen I Antibody LS-C121631
Rabbit Polyclonal to Human Collagen I
Human
ELISA ICC IHC IHC-Fr WB
Unconjugated
1000µl  $560.00

Collagen I Antibody LS-C664059
Rabbit Polyclonal to Mouse Collagen I
Mouse
ICC IHC IP WB
Unconjugated
20µl 0.5mg/ml  $195.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $285.00; 1ml 0.5mg/ml  $485.00; 10ml 0.5mg/ml  $1,935.00

Collagen I Antibody LS-C349972
Goat Polyclonal (IgG) to Human Collagen I
Human
ELISA ICC IHC WB
Unconjugated
200µg 0.4mg/ml  $445.00

Collagen I Antibody LS-C744035
Rabbit Polyclonal to Mouse Collagen I
Chicken, Mouse, Human
ELISA IF IHC-P RIA WB
Unconjugated
0.5ml  $860.00

Collagen I Antibody LS-C744036
Rabbit Polyclonal to Mouse Collagen I
Chicken, Mouse, Human
ELISA IF IHC-P RIA WB
Unconjugated
0.1ml  $475.00
Showing 1-25 of 152 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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