COL6A3 / Collagen VI Alpha 3

collagen, type VI, alpha 3

COL6A3 / Collagen VI Alpha 3 is the alpha-3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha-3 chain of type VI collagen is much larger than the alpha-1 and -2 chains. This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, that are found in the amino terminal globular domain of all the alpha chains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in the type VI collagen genes are associated with Bethlem myopathy, a rare autosomal dominant proximal myopathy with early childhood onset. Mutations in this gene are also a cause of Ullrich congenital muscular dystrophy, also referred to as Ullrich scleroatonic muscular dystrophy, an autosomal recessive congenital myopathy that is more severe than Bethlem myopathy. Multiple transcript variants have been identified, but the full-length nature of only some of these variants has been described.

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Products

Proteins (6)

Type

Recombinant (6)

Target

COL6A3 / Collagen VI Alpha 3 (6)

Publications

No (6)

Tag

6His-B2M, N-terminus (1)

6His-SUMO, N-terminus (1)

His,N-terminus (1)

His-T7 (2)

Species

Human (5)

Mouse (1)

Source

E. coli (4)

HEK 293 Cells (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human COL6A3 / Collagen VI Alpha 3 Protein (Recombinant) (Thr3101-Thr3177) - LS-G97331

Source:

HEK 293 Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

8.5 kDa

Price:

100 µg/$843

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Mouse COL6A3 / Collagen VI Alpha 3 Protein (Recombinant His-T7) (aa2009-2205) - LS-G24651

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.2 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human COL6A3 / Collagen VI Alpha 3 Protein (Recombinant 6His-SUMO, N-terminus) - LS-G136903

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Molecular Weight:

50.5 kDa

Price:

100 µg/$1,128; 20 µg/$721

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Human COL6A3 / Collagen VI Alpha 3 Protein (Recombinant 6His-B2M, N-terminus) - LS-G136902

Source:

E. coli

Tag:

6His-B2M, N-terminus

Molecular Weight:

48.5 kDa

Price:

100 µg/$1,128; 20 µg/$721

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Human COL6A3 / Collagen VI Alpha 3 Protein (Recombinant His,N-terminus) - LS-G138238

Source:

HEK 293 Cells

Tag:

His,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

11.4 kDa

Price:

100 µg/$843

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Human COL6A3 / Collagen VI Alpha 3 Protein (Recombinant His-T7) (aa463-624) - LS-G14802

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.4 kDa

Price:

50 µg/$402; 10 µg/$275; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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