COL4A3 / Tumstatin

collagen, type IV, alpha 3 (Goodpasture antigen)

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

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Products

Proteins (3)

Type

Recombinant (3)

Target

COL4A3 / Tumstatin (3)

Publications

No (3)

Tag

Fc, N-terminus (1)

His (1)

His-GST (1)

Species

Human (2)

Rat (1)

Source

E. coli (2)

HEK 293 Cells (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human COL4A3 / Tumstatin Protein (Recombinant His-GST) (aa1428-1670) - LS-G14805

Source:

E. coli

Tag:

His-GST

Molecular Weight:

58.9 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human COL4A3 / Tumstatin Protein (Recombinant His) (aa1446-1667) - LS-G20621

Source:

E. coli

Tag:

His

Molecular Weight:

30.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Rat COL4A3 / Tumstatin Protein (Recombinant Fc, N-terminus) (Gly1426-His1670) - LS-G138334

Source:

HEK 293 Cells

Tag:

Fc, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

55.2 kDa

Price:

100 µg/$843

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