COL4A1 / Collagen IV Alpha1

collagen, type IV, alpha 1

COL4A1 / Collagen IV Alpha1 is a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.

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Proteins (3)

Type

Recombinant (3)

Target

COL4A1 / Collagen IV Alpha1 (3)

Publications

No (3)

Tag

GST (1)

His, N-Terminal (1)

His-SUMO (1)

Species

Human (3)

Source

E. coli (3)

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Human COL4A1 / Collagen IV Alpha1 Protein (Recombinant His, N-Terminal) (aa1444-1669) - LS-G11688

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

30.7 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human COL4A1 / Collagen IV Alpha1 Protein (Recombinant His-SUMO) (aa1445-1669) - LS-G20620

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

40.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human COL4A1 / Collagen IV Alpha1 Protein (Recombinant GST) (aa30-167) - LS-G22542

Source:

E. coli

Tag:

GST

Molecular Weight:

40.3 kD

Price:

100 µg/$420; 20 µg/$323; 1 mg/$1,355

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