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COL4A1 / Collagen IV Alpha1

collagen, type IV, alpha 1

COL4A1 / Collagen IV Alpha1 is a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.

Gene Name: collagen, type IV, alpha 1
Family/Subfamily: Collagen , not assigned-Collagen
Synonyms: COL4A1, Arresten, COL4A1 NC1 domain, Collagen alpha-1(IV) chain, Collagen, type IV, alpha 1, HANAC, ICH, POREN1
Target Sequences: NM_001845 NP_001836.3 P02462

Publications (1)

1
Defining the Extracellular Matrix of Rhabdomyosarcoma. Xiaolei Lian, J Steffan Bond, Narendra Bharathy, Sergei P Boudko, Elena Pokidysheva, Jack F Shern, Melvin Lathara, Takako Sasaki, Teagan Settelmeyer, Megan M Cleary, Ayeza Bajwa, Ganapati Srinivasa, Christopher P Hartley, Hans Peter Bächinger, Atiya Mansoor, Sakir H Gultekin, Noah E Berlow, Charles Keller. Frontiers in oncology. 2021 March;11:601957. [Full Text Article] [PubMed:33708626] [PMC:PMC7942227] Related Antibodies: LS-C175972.

☰ Filters
Antibodies (34)
ELISA Kits (23)
Proteins (3)
Cell-Based (1)
Custom (2)
Primary (34)
Recombinant (3)
Sandwich (16)
Sandwich CLIA (4)
COL4A1 / Collagen IV Alpha1 (60)
Human (43)
Mouse (19)
Rat (8)
Bat (1)
Bovine (2)
Chicken (2)
Dog (1)
Guinea pig (1)
Hamster (1)
Horse (1)
Monkey (1)
Pig (2)
Porcine (1)
Rabbit (1)
Sheep (1)
IHC (16)
IHC-P (10)
WB (29)
ELISA (17)
IF (2)
Peptide-ELISA (1)
rabbit (32)
mouse (2)
Product Group
IHCPlus (1)
IgG (22)
IgG1 (1)
monoclonal mc (2)
polyclonal pc (32)
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96-Well Microplate (4)
96-Well Strip Plate (16)
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APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (16)
aa1444-1669 (8)
aa27-54 (6)
aa1445-1669 (2)
30-110 aa, N-terminal (1)
Gly46 (1)
N-Terminus (1)
aa1654-1669 (1)
aa30-167 (1)
No (59)
Yes (1)
Adherent Cell Cultures (1)
Cell Culture Supernatants (1)
Cell Lysates (1)
Plasma (16)
Serum (16)
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His, N-Terminal (1)
His-SUMO (1)
Human (3)
E. coli (3)
COL4A1 / Collagen IV Alpha1 Antibody - Immunohistochemical analysis of Collagen 4 alpha 1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Chicken, Bovine, Mouse, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
COL4A1 / Collagen IV Alpha1 Antibody - IHC of Collagen IV (G46) pAb in paraffin-embedded human breast carcinoma tissue.
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (Gly46) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
COL4A1 / Collagen IV Alpha1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
COL4A1 / Collagen IV Alpha1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
4.69 - 300 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
COL4A1 / Collagen IV Alpha1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
COL4A1 / Collagen IV Alpha1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
COL4A1 / Collagen IV Alpha1 Antibody - 1/100 staining human colon cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary antibody.
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
COL4A1 / Collagen IV Alpha1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
COL4A1 / Collagen IV Alpha1 Protein - Recombinant Collagen Type IV Alpha 1 By SDS-PAGE
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E. coli
His, N-Terminal
30.7 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
COL4A1 / Collagen IV Alpha1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
COL4A1 / Collagen IV Alpha1 Antibody - Collagen IV antibody IHC-paraffin: Human Lung Cancer Tissue.
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (aa1445-1669) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
COL4A1 / Collagen IV Alpha1 Antibody - Immunohistochemistry of paraffin-embedded human lung tissue using COL4A1 Antibody at dilution of 1:100
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$294; 100 µg/$360
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
COL4A1 / Collagen IV Alpha1 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (aa30-167) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
COL4A1 / Collagen IV Alpha1 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
COL4A1 / Collagen IV Alpha1 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
COL4A1 / Collagen IV Alpha1 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
COL4A1 / Collagen IV Alpha1 Antibody - Western blot testing of Collagen IV antibody and Lane 1: MCF-7; 2: SCG; 3: SW620 cell lysate
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (aa1654-1669) Antibody
Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
WB
Unconjugated
100 µg/$575
COL4A1 / Collagen IV Alpha1 Antibody - Western Blot; Sample: Recombinant COL4a1, Human.
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (aa1444-1669) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$565; 1 ml/$682; 2 ml/$919; 5 ml/$1,549
COL4A1 / Collagen IV Alpha1 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
COL4A1 / Collagen IV Alpha1 Protein
Select
E. coli
His-SUMO
40.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
COL4A1 / Collagen IV Alpha1 ELISA Kit
Select
Cell-Based
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
COL4A1 / Collagen IV Alpha1 Antibody - Western blot of COL4A1 antibody
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COL4A1 / Collagen IV Alpha1 Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Viewing 1-25 of 60 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).