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COL2A1 / Collagen II Alpha 1

collagen, type II, alpha 1

COL2A1 / Collagen II Alpha 1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.

Gene Name: collagen, type II, alpha 1
Family/Subfamily: Collagen , not assigned-Collagen
Synonyms: COL2A1, Alpha-1 type II collagen, Cartilage collagen, COL11A3, Collagen alpha 1(ii), Collagen, type II, alpha 1, Collagen alpha-1(II) chain, Chondrocalcin, ANFH, AOM, SEDC
Target Sequences: NM_001844 NP_001835.3 P02458

Publications (4)

1
Atelocollagen promotes chondrogenic differentiation of human adipose-derived mesenchymal stem cells. Seon Ae Kim, Yoo Joon Sur, Mi-La Cho, Eun Jeong Go, Yun Hwan Kim, Asode Ananthram Shetty, Seok Jung Kim. Scientific reports. 2020 June;10:10678. [Full Text Article] [PubMed:32606308] [PMC:PMC7327030]
2
CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1. Go Jokoji, Shingo Maeda, Kazuki Oishi, Toshiro Ijuin, Masahiro Nakajima, Hiroki Tawaratsumida, Ichiro Kawamura, Hiroyuki Tominaga, Eiji Taketomi, Shiro Ikegawa, Noboru Taniguchi. The Journal of biological chemistry. 2021 Aug;;297:100994. [Full Text Article] [PubMed:34298017] [PMC:PMC8363834] Related Antibodies: LS-C175971.
3
MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8. Yeyang Wang, Xiaoyu Zheng, Dixin Luo, Wangyang Xu, Xiaozhong Zhou. BMC musculoskeletal disorders. 2022 September;23:872. [Full Text Article] [PubMed:36127685] [PMC:PMC9487131] Related Antibodies: LS-C800256.
4
Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation. Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S. The Journal of biological chemistry. 2014 Apr;289:9865-79. [Full Text Article] [PubMed:24563464] [PMC:PMC3975031] Related Antibodies: LS-C175971.
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Proteins (7)
Recombinant (7)
COL2A1 / Collagen II Alpha 1 (7)
No (7)
GST (1)
His (5)
His-GST-S (1)
Human (4)
Mouse (1)
Rabbit (1)
Rat (1)
E. coli (5)
Human Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (2)
COL2A1 / Collagen II Alpha 1 Protein - Recombinant  Collagen Type II Alpha 1 By SDS-PAGE
Select
E. coli
His
13.5 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,745
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
29.8 kDa
50 µg/$721
COL2A1 / Collagen II Alpha 1 Protein
Select
E. coli
His
10.6 kDa
10 µg/$281; 50 µg/$442; 100 µg/$707; 200 µg/$885; 1 mg/$1,994; 500 µg/$1,534; 5 mg/$3,095; 2 mg/$2,181
COL2A1 / Collagen II Alpha 1 Protein - Recombinant Collagen Type II Alpha 1 By SDS-PAGE
Select
E. coli
His
10.3 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
COL2A1 / Collagen II Alpha 1 Protein - Recombinant  Collagen Type II Alpha 1 By SDS-PAGE
Select
E. coli
His-GST-S
51.4 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
COL2A1 / Collagen II Alpha 1 Protein - 12.5% SDS-PAGE of human COL2A1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
55.22 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
245 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
27.06 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).