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COL2A1 / Collagen II Alpha 1

collagen, type II, alpha 1

COL2A1 / Collagen II Alpha 1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.

Gene Name: collagen, type II, alpha 1
Family/Subfamily: Collagen , not assigned-Collagen
Synonyms: COL2A1, Alpha-1 type II collagen, Cartilage collagen, COL11A3, Collagen alpha 1(ii), Collagen, type II, alpha 1, Collagen alpha-1(II) chain, Chondrocalcin, ANFH, AOM, SEDC
Target Sequences: NM_001844 NP_001835.3 P02458

Publications (4)

1
Atelocollagen promotes chondrogenic differentiation of human adipose-derived mesenchymal stem cells. Seon Ae Kim, Yoo Joon Sur, Mi-La Cho, Eun Jeong Go, Yun Hwan Kim, Asode Ananthram Shetty, Seok Jung Kim. Scientific reports. 2020 June;10:10678. [Full Text Article] [PubMed:32606308] [PMC:PMC7327030]
2
CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1. Go Jokoji, Shingo Maeda, Kazuki Oishi, Toshiro Ijuin, Masahiro Nakajima, Hiroki Tawaratsumida, Ichiro Kawamura, Hiroyuki Tominaga, Eiji Taketomi, Shiro Ikegawa, Noboru Taniguchi. The Journal of biological chemistry. 2021 Aug;;297:100994. [Full Text Article] [PubMed:34298017] [PMC:PMC8363834] Related Antibodies: LS-C175971.
3
MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8. Yeyang Wang, Xiaoyu Zheng, Dixin Luo, Wangyang Xu, Xiaozhong Zhou. BMC musculoskeletal disorders. 2022 September;23:872. [Full Text Article] [PubMed:36127685] [PMC:PMC9487131] Related Antibodies: LS-C800256.
4
Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation. Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S. The Journal of biological chemistry. 2014 Apr;289:9865-79. [Full Text Article] [PubMed:24563464] [PMC:PMC3975031] Related Antibodies: LS-C175971.
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ELISA Kits (15)
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COL2A1 / Collagen II Alpha 1 (15)
Human (6)
Mouse (2)
Rat (5)
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12 x 8-Well Microstrips (1)
96-Well Microplate (2)
96-Well Strip Plate (12)
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Plasma (12)
Serum (12)
Tissue Homogenates (2)
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.63 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$834
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
125 - 8000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
COL2A1 / Collagen II Alpha 1 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
COL2A1 / Collagen II Alpha 1 ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
COL2A1 / Collagen II Alpha 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Sandwich
96-Well Microplate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
COL2A1 / Collagen II Alpha 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
100 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
COL2A1 / Collagen II Alpha 1 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
COL2A1 / Collagen II Alpha 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
46.88 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$893
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).