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COL25A1 / Collagen XXV
collagen, type XXV, alpha 1
COL25A1 / Collagen XXV is a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | collagen, type XXV, alpha 1 |
| Synonyms: | COL25A1, AMY, CLAC-P, CLAC, CLACP, Collagen, type XXV, alpha 1, Collagen alpha-1(XXV) chain |
| Target Sequences: | NM_032518 NP_115907.2 Q9BXS0 |
Publications (1)
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