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COL10A1 / Collagen X

collagen, type X, alpha 1

COL10A1 / Collagen X is the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).

Gene Name: collagen, type X, alpha 1
Family/Subfamily: Collagen , not assigned-Collagen
Synonyms: COL10A1, Collagen alpha-1(X) chain, Collagen, type X, alpha 1
Target Sequences: NM_000493 NP_000484.2 Q03692

Publications (9)

1
Diagnostic role of circulating extracellular matrix-related proteins in non-small cell lung cancer. Andriani F, Landoni E, Mensah M, Facchinetti F, Miceli R, Tagliabue E, Giussani M, Callari M, De Cecco L, Colombo MP, Roz L, Pastorino U, Sozzi G. BMC cancer. 2018 September;18:899. [Full Text Article] [PubMed:30227835] [PMC:PMC6145327]
2
MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN. Chen L, Li Q, Wang J, Jin S, Zheng H, Lin J, He F, Zhang H, Ma S, Mei J, Yu J. Journal of cellular and molecular medicine. 2017 December;21:3347-3359. [Full Text Article] [PubMed:28609022] [PMC:PMC5706578]
3
Investigating the role of culture conditions on hypertrophic differentiation in human cartilage endplate cells. Katherine Lakstins, Taylor Yeater, Lauren Arnold, Safdar Khan, Judith A Hoyland, Devina Purmessur. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2020 April; [Full Text Article] [PubMed:32285966]
4
Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation. Megan M Simonds, Amanda R Schlefman, Suzanne M McCahan, Kathleen E Sullivan, Carlos D Rose, AnneMarie C Brescia. Pediatric rheumatology online journal. 2020 November;18:89. [Full Text Article] [PubMed:33198759] [PMC:PMC7670793]
5
The culture microenvironment of juvenile idiopathic arthritis synovial fibroblasts is favorable for endochondral bone formation through BMP4 and repressed by chondrocytes. Megan M Simonds, Amanda R Schlefman, Suzanne M McCahan, Kathleen E Sullivan, Carlos D Rose, Anne Marie C Brescia. Pediatric rheumatology online journal. 2021 May;19:72. [Full Text Article] [PubMed:33980237] [PMC:PMC8117630]
6
Potential of the Stromal Matricellular Protein Periostin as a Biomarker to Improve Risk Assessment in Prostate Cancer. Valentina Doldi, Mara Lecchi, Silva Ljevar, Maurizio Colecchia, Elisa Campi, Giovanni Centonze, Cristina Marenghi, Tiziana Rancati, Rosalba Miceli, Paolo Verderio, Riccardo Valdagni, Paolo Gandellini, Nadia Zaffaroni. International journal of molecular sciences. 2022 July;23: [Full Text Article] [PubMed:35887333] [PMC:PMC9324424]
7
Characterization of the human intervertebral disc cartilage endplate at the molecular, cell, and tissue levels. Katherine Lakstins, Lauren Arnold, Gilian Gunsch, David Flanigan, Safdar Khan, Nikhit Gadde, Blain Jones, Gunjan Agarwal, Devina Purmessur. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2021 September;39:1898-1907. [Full Text Article] [PubMed:32915471]
8
Extracellular matrix proteins as diagnostic markers of breast carcinoma. Marta Giussani, Elena Landoni, Giuseppe Merlino, Federica Turdo, Silvia Veneroni, Biagio Paolini, Vera Cappelletti, Rosalba Miceli, Rosaria Orlandi, Tiziana Triulzi, Elda Tagliabue. Journal of cellular biochemistry. 2018 August;233:6280-6290. [Full Text Article] [PubMed:29521413]
9
EGFR Signaling Is Required for Maintaining Adult Cartilage Homeostasis and Attenuating Osteoarthritis Progression. Yulong Wei, Xiaoyuan Ma, Hao Sun, Tao Gui, Jun Li, Lutian Yao, Leilei Zhong, Wei Yu, Biao Han, Charles L Nelson, Lin Han, Frank Beier, Motomi Enomoto-Iwamoto, Jaimo Ahn, Ling Qin. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2022 May;37:1012-1023. [Full Text Article] [PubMed:35191092] [PMC:PMC9098673] Related Antibodies: LS-C667746.
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).