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CNTN1 / gp135 / Contactin 1
contactin 1
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
| Gene Name: | contactin 1 |
| Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
| Synonyms: | CNTN1, Contactin, Contactin 1, Glycoprotein gp135, gp135, Neural cell surface protein F3, Contactin-1 |
| Target Sequences: | NM_001843 NP_001834.2 Q12860 |
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