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CNTF
ciliary neurotrophic factor
CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
| Gene Name: | ciliary neurotrophic factor |
| Synonyms: | CNTF, Ciliary neurotrophic factor, HCNTF |
| Target Sequences: | NM_000614 NP_000605.1 P26441 |
Publications (1)
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