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CNOT8
CCR4-NOT transcription complex, subunit 8
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
| Gene Name: | CCR4-NOT transcription complex, subunit 8 |
| Synonyms: | CNOT8, CAF1-like protein, CALIFp, CCR4-associated factor 8, CAF2, HCAF1, POP2, CAF1, CALIF |
| Target Sequences: | NM_004779 NP_004770.4 Q9UFF9 |
Publications (1)
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