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CNOT7
CCR4-NOT transcription complex, subunit 7
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
| Gene Name: | CCR4-NOT transcription complex, subunit 7 |
| Synonyms: | CNOT7, BTG1-binding factor 1, BTG1 binding factor 1, CAF-1, CCR4-associated factor 1, CAF1, HCAF-1 |
| Target Sequences: | NM_013354 NP_037486.2 Q9UIV1 |
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