CNOT6

CCR4-NOT transcription complex, subunit 6

Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

CNOT6 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human CNOT6 Protein (Recombinant GST, N-terminus) (aa112-210) - LS-G62952

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CNOT6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90132

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.1 kDa

Price:

20 µg/$215

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Human CNOT6 Protein (Recombinant GST) (Full Length) - LS-G34723

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

36.7 kDa

Price:

2 µg/$439

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CNOT6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113206

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.1 kDa

Price:

100 µg/$710

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