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CNOT2
CCR4-NOT transcription complex, subunit 2
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.
| Gene Name: | CCR4-NOT transcription complex, subunit 2 |
| Synonyms: | CNOT2, CDC36, CCR4-associated factor 2, NOT2H, HSPC131, NOT2 |
| Target Sequences: | NM_014515 NP_055330.1 Q9NZN8 |
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