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CNKSR2 is a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | connector enhancer of kinase suppressor of ras 2 |
Synonyms: | CNKSR2, CNK2, Connector enhancer of KSR 2, Connector enhancer of KSR2, CNK homolog protein 2, MAGUIN, KIAA0902 |
Target Sequences: | NM_014927 NP_055742.2 Q8WXI2 |
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