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CNGB3 / CNG Channel Beta-3
cyclic nucleotide gated channel beta 3
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
| Gene Name: | cyclic nucleotide gated channel beta 3 |
| Family/Subfamily: | Ion Channel , Cyclic nucleotide gated channel |
| Synonyms: | CNGB3, ACHM1, ACHM3, Cngbeta2, CCNC2, CNG channel beta-3, CNG6 |
| Target Sequences: | NM_019098 NP_061971.3 Q9NQW8 |
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