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CNGA4
cyclic nucleotide gated channel alpha 4
Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
| Gene Name: | cyclic nucleotide gated channel alpha 4 |
| Family/Subfamily: | Ion Channel , Cyclic nucleotide gated channel |
| Synonyms: | CNGA4, CNG2B, Cgn2, CNG channel alpha-4, CNG-4, CNCA2, CNG4, CNG5, OCNC2, OCNCBETA, OCNCb, CNGB2 |
| Target Sequences: | AX465594 CAD42376.1 Q8IV77 |
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