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CNGA3
cyclic nucleotide gated channel alpha 3
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
| Gene Name: | cyclic nucleotide gated channel alpha 3 |
| Family/Subfamily: | Ion Channel , Cyclic nucleotide gated channel |
| Synonyms: | CNGA3, CCNCa, CCNCalpha, CCNC1, CNG channel alpha-3, CNG3, ACHM2, Achromatopsia 2, MCNG3, CNCG3, CNG-3 |
| Target Sequences: | NM_001298 NP_001289.1 Q16281 |
Publications (1)
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