CML / BCR

breakpoint cluster region

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

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Products

ELISA Kits (4)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Competitive EIA (1)

Target

CML / BCR (4)

Reactivity

Human (3)

Mouse (3)

Format

96-Well Microplate (3)

96-Well Strip Plate (1)

Publications

No (4)

Sample Type

Adherent Cell Cultures (3)

Plasma (1)

Serum (1)

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CML / BCR (Competitive EIA) ELISA Kit - LS-F10643

Type:

Competitive EIA

Format:

96-Well Strip Plate

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse/Human Phospho-CML / BCR (Tyr177) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1465

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human CML / BCR (Cell-Based ELISA) ELISA Kit - LS-F1825

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Mouse/Human Phospho-CML / BCR (Tyr360) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1292

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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