CML / BCR

breakpoint cluster region

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

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Antibodies (65)

Proteins (6)

ELISA Kits (4)

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Cell-Based (1)

Cell-Based Phosphorylation (2)

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Over-Expression Lysate (2)

Primary (65)

Recombinant (4)

Target

CML / BCR (75)

Reactivity

Human (58)

Mouse (38)

Rat (11)

Chicken (1)

Chimpanzee (3)

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ICC (5)

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IP (2)

Peptide-ELISA (7)

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rabbit (62)

mouse (3)

Isotype

IgG (33)

IgG1 (2)

IgG2a,k (1)

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monoclonal mc (3)

polyclonal pc (62)

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6B5E12 (1)

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aa1042-1243 (8)

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120-200 aa (2)

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300-380 aa (1)

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No (75)

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Adherent Cell Cultures (3)

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Mouse (1)

Source

293T Cells (1)

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Wheat Germ Extract (1)

Select

CML / BCR Antibody (phospho-Tyr360) LS-C358919

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (pTyr360) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$263; 100 µl/$315; 200 µl/$379

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CML / BCR Antibody (phospho-Tyr360) LS-C801017

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (pTyr360) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

CML / BCR Antibody (phospho-Tyr360) LS-C822121

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (pTyr360) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

CML / BCR Antibody (phospho-Tyr360) LS-C416534

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (pTyr360) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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CML / BCR Antibody (phospho-Tyr360) LS-C198681

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (pTyr360) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

CML / BCR Antibody (aa1221-1271) LS-C288817

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (aa1221-1271) Antibody

Reactivity:

Human

Applications:

Flo, ICC, IF, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

CML / BCR Antibody (300-380 aa) LS-C381491

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (300-380 aa) Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

CML / BCR Antibody (aa50-100) LS-C288812

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (aa50-100) Antibody

Reactivity:

Human

Applications:

Flo, ICC, IF, IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

CML / BCR Antibody (clone 1E11G12) LS-C682521

Antibody:

CML / BCR Mouse anti-Human Monoclonal (1E11G12) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

CML / BCR Antibody (phospho-Tyr177) LS-C12203

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (pTyr177) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$689

Select

CML / BCR Antibody (clone 2E5) LS-C196741

Antibody:

CML / BCR Mouse anti-Human Monoclonal (2E5) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

CML / BCR Antibody LS-C831566

Antibody:

CML / BCR Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439

Select

CML / BCR Antibody (phospho-Tyr177) LS-C801013

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (pTyr177) Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

CML / BCR Antibody LS-C659387

Antibody:

CML / BCR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

CML / BCR Antibody (120-200 aa) LS-C382265

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (120-200 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

CML / BCR Antibody LS-C408184

Antibody:

CML / BCR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

CML / BCR Antibody (aa50-100) LS-C286638

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (aa50-100) Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

Select

CML / BCR Antibody (clone 6B5E12) LS-C682520

Antibody:

CML / BCR Mouse anti-Human Monoclonal (6B5E12) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

CML / BCR Antibody LS-C808628

Antibody:

CML / BCR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

CML / BCR Antibody (N-Terminus) LS-C358430

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

CML / BCR Antibody (aa331-380) LS-C117800

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (aa331-380) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

CML / BCR Antibody LS-C822122

Antibody:

CML / BCR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

CML / BCR Antibody (Asp171) LS-C175936

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (Asp171) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

CML / BCR Antibody LS-C417413

Antibody:

CML / BCR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

CML / BCR Antibody (phospho-Tyr177) LS-C335865

Antibody:

CML / BCR Rabbit anti-Human Polyclonal (pTyr177) Antibody

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$341; 100 µl/$431; 200 µl/$539

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