CLP1

cleavage and polyadenylation factor I subunit 1

Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

CLP1 (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (5)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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CLP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126035

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.5 kDa

Price:

100 µg/$494

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Human CLP1 Protein (Recombinant GST) (Full Length) - LS-G32430

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

74 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CLP1 Protein (Recombinant GST, N-terminus) (aa316-425) - LS-G61699

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CLP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68266

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.5 kDa

Price:

20 µg/$1,107

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Human CLP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81783

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.5 kDa

Price:

20 µg/$150

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Human CLP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81785

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.5 kDa

Price:

20 µg/$150

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CLP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100931

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.5 kDa

Price:

100 µg/$494

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