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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CLP1

cleavage and polyadenylation factor I subunit 1

Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

Gene Name: cleavage and polyadenylation factor I subunit 1
Synonyms: CLP1, HEAB, Polynucleotide kinase Clp1, ATP/GTP-binding protein, HClp1
Target Sequences: NM_006831 NP_006822.1 Q92989

Filtered By: None
Target
CLP1 (25)
Reactivity
Human (25)
Mouse (8)
Rat (8)
Bat (8)
Bovine (9)
Chicken (4)
Chimpanzee (3)
Dog (8)
Gibbon (3)
Guinea pig (8)
Horse (8)
Monkey (8)
Orangutan (3)
Pig (8)
Rabbit (8)
Xenopus (4)
Application
IHC (1)
IHC-P (1)
WB (25)
ELISA (15)
ICC (1)
Host
rabbit (18)
mouse (7)
Isotype
IgG (9)
IgG2a,k (7)
Clonality
monoclonal mc (7)
polyclonal pc (18)
Format
AP Conjugated (2)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (7)
Epitope
aa308-336 (8)
aa103-152 (4)
aa264-313 (4)
aa142-371 (1)
aa316-426 (1)
Publications
No (25)
Showing 1-25 of 25 results

CLP1 Antibody (aa142-371) LS-C186405
Rabbit Polyclonal (IgG) to Human CLP1
Bovine, Human
ICC IHC IHC-P WB
Unconjugated
100µl 0.27mg/ml  $335.00
IHC of paraffin-embedded HS578T xenograft using CLP1 antibody at 1:100 dilution.
Immunofluorescence of paraformaldehyde-fixed HeLa using CLP1 antibody at 1:200 dilution.
IHC of paraffin-embedded HS578T xenograft using CLP1 antibody at 1:100 dilution.
Immunofluorescence of paraformaldehyde-fixed HeLa using CLP1 antibody at 1:200 dilution.

CLP1 Antibody (aa316-426) LS-C306996
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA WB
Unconjugated
100µg  $560.00

CLP1 Antibody (HRP) LS-C541515
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA WB
HRP Conjugated
100µl  $710.00

CLP1 Antibody (Biotin) LS-C521384
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA WB
Biotin Conjugated
100µl  $710.00

CLP1 Antibody (FITC) LS-C531427
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA WB
FITC Conjugated
100µl  $710.00

CLP1 Antibody (AP) LS-C503458
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA WB
AP Conjugated
100µl  $710.00

CLP1 Antibody (APC) LS-C513168
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA WB
APC Conjugated
100µl  $710.00

CLP1 Antibody (PE) LS-C649629
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA WB
PE Conjugated
100µl  $710.00

CLP1 Antibody (aa308-336) LS-C320453
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA WB
Unconjugated
200µl  $530.00

CLP1 Antibody (aa308-336, Biotin) LS-C213331
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

CLP1 Antibody (aa308-336, FITC) LS-C213332
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA WB
FITC Conjugated
200µl  $680.00

CLP1 Antibody (aa308-336, AP) LS-C213330
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA WB
AP Conjugated
200µl  $680.00

CLP1 Antibody (aa308-336, APC) LS-C213329
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA WB
APC Conjugated
200µl  $680.00

CLP1 Antibody (aa308-336, Azide-free, HRP) LS-C213333
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

CLP1 Antibody (aa308-336, PE) LS-C213334
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA WB
PE Conjugated
200µl  $680.00

CLP1 Antibody LS-C664649
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA WB
Unconjugated
100µg  $355.00

CLP1 Antibody (aa264-313) LS-C151653
Rabbit Polyclonal to Human CLP1
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Human, Monkey
WB
Unconjugated
50µg  $365.00
CLP1 antibody Western Blot of RPMI-8226.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLP1 antibody Western Blot of RPMI-8226.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CLP1 Antibody (aa264-313, HRP) LS-C471824
Rabbit Polyclonal to Human CLP1
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Chimpanzee, Gibbon, Orangutan, Human, Monkey
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
CLP1 antibody Western Blot of RPMI-8226.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLP1 antibody Western Blot of RPMI-8226.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CLP1 Antibody (aa264-313, Biotin) LS-C471822
Rabbit Polyclonal to Human CLP1
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Chimpanzee, Gibbon, Orangutan, Human, Monkey
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
CLP1 antibody Western Blot of RPMI-8226.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLP1 antibody Western Blot of RPMI-8226.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CLP1 Antibody (aa264-313, FITC) LS-C471823
Rabbit Polyclonal to Human CLP1
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Chimpanzee, Gibbon, Orangutan, Human, Monkey
WB
FITC Conjugated
100µl 1mg/ml  $385.00
CLP1 antibody Western Blot of RPMI-8226.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLP1 antibody Western Blot of RPMI-8226.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CLP1 Antibody (aa103-152) LS-C151654
Rabbit Polyclonal to Human CLP1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
50µg  $365.00
CLP1 antibody Western Blot of HepG2 cell lysate. CLP1 is supported by BioGPS gene expression data to be expressed in HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLP1 antibody Western Blot of HepG2 cell lysate. CLP1 is supported by BioGPS gene expression data to be expressed in HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CLP1 Antibody (aa103-152, HRP) LS-C471827
Rabbit Polyclonal to Human CLP1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
CLP1 antibody Western Blot of HepG2 cell lysate. CLP1 is supported by BioGPS gene expression data to be expressed in HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLP1 antibody Western Blot of HepG2 cell lysate. CLP1 is supported by BioGPS gene expression data to be expressed in HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CLP1 Antibody (aa103-152, Biotin) LS-C471825
Rabbit Polyclonal to Human CLP1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
CLP1 antibody Western Blot of HepG2 cell lysate. CLP1 is supported by BioGPS gene expression data to be expressed in HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLP1 antibody Western Blot of HepG2 cell lysate. CLP1 is supported by BioGPS gene expression data to be expressed in HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CLP1 Antibody (aa103-152, FITC) LS-C471826
Rabbit Polyclonal to Human CLP1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
FITC Conjugated
100µl 1mg/ml  $385.00
CLP1 antibody Western Blot of HepG2 cell lysate. CLP1 is supported by BioGPS gene expression data to be expressed in HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLP1 antibody Western Blot of HepG2 cell lysate. CLP1 is supported by BioGPS gene expression data to be expressed in HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CLP1 Antibody (aa308-336) LS-C168850
Rabbit Polyclonal to Human CLP1
Human
WB
Unconjugated
400µl  $305.00
CLP1 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The CLP1 antibody detected the CLP1 protein (arrow).
CLP1 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The CLP1 antibody detected the CLP1 protein (arrow).
Showing 1-25 of 25 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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