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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CLP1

cleavage and polyadenylation factor I subunit 1

Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810). Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810). Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

Gene Name: cleavage and polyadenylation factor I subunit 1
Synonyms: CLP1, HEAB, Polynucleotide kinase Clp1, ATP/GTP-binding protein, HClp1
Target Sequences: NM_006831 NP_006822.1 Q92989

Viewing 1-25 of 29 items
CLP1 Antibody - IHC of paraffin-embedded HS578T xenograft using CLP1 antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human CLP1
Bovine, Human
ICC, IHC, IHC-P, WB
Unconjugated
100µl   0.27mg/ml   $355.00
Select
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA, WB
Unconjugated
100µg   $560.00
Select
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA, WB
HRP Conjugated
100µl   $710.00
Select
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA, WB
Biotin Conjugated
100µl   $710.00
Select
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA, WB
FITC Conjugated
100µl   $710.00
Select
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA, WB
APC Conjugated
100µl   $710.00
Select
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA, WB
PE Conjugated
100µl   $710.00
Select
Mouse Monoclonal (IgG2a,k) to Human CLP1
Human
ELISA, WB
AP Conjugated
100µl   $710.00
Select
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CLP1
Human
ELISA, WB
Unconjugated
100µg   $355.00
Select
Rabbit Polyclonal to Human CLP1
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00
CLP1 Antibody - Western blot analysis of CLP1 using LOVO cells whole cells lysates
Select
Rabbit Polyclonal (IgG) to Human CLP1
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
CLP1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY CLP1. (Right lane) cDNA for 48 hrs and lysed
Select
Mouse Monoclonal [clone OTI2D2] (IgG1) to Human CLP1
Rat, Human
WB
Unconjugated
100µl   1mg/ml   $345.00
CLP1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY CLP1. (Right lane) cDNA for 48 hrs and lysed
Select
Mouse Monoclonal [clone OTI1H7] (IgG1) to Human CLP1
Rat, Human
WB
Unconjugated
100µl   1mg/ml   $345.00
CLP1 Antibody - CLP1 antibody Western Blot of HepG2 cell lysate. CLP1 is supported by BioGPS gene expression data to be expressed in HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human CLP1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
CLP1 Antibody - CLP1 antibody Western Blot of HepG2 cell lysate. CLP1 is supported by BioGPS gene expression data to be expressed in HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human CLP1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
CLP1 Antibody - CLP1 antibody Western Blot of HepG2 cell lysate. CLP1 is supported by BioGPS gene expression data to be expressed in HepG2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human CLP1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
WB
FITC Conjugated
100µl   1mg/ml   $385.00
CLP1 Antibody - CLP1 antibody Western Blot of RPMI-8226.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human CLP1
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
CLP1 Antibody - CLP1 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The CLP1 antibody detected the CLP1 protein (arrow).
Select
Rabbit Polyclonal to Human CLP1
Human
WB
Unconjugated
400µl   $325.00

Viewing 1-25 of 29 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).