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CLK1 / CLK

CDC-like kinase 1

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.

Gene Name: CDC-like kinase 1
Family/Subfamily: Protein Kinase , LAMMER/Clk
Synonyms: CLK1, CDC-like kinase 1, CDC28/CDC2-like kinase, CLK, Protein kinase clk1, Protein tyrosine kinase STY, STY, Protein Kinase CLK
Target Sequences: NM_004071 NP_004062.2 P49759

Publications (1)

1
Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum. Pol Andrés-Benito, Margarita Carmona, Mónica Jordán, Joaquín Fernández-Irigoyen, Enrique Santamaría, José Antoni Del Rio, Isidro Ferrer. International journal of molecular sciences. 2022 January;23: [Full Text Article] [PubMed:35054902] [PMC:PMC8775896] Related Antibodies: LS-C382760.

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Products
Antibodies (29)
Primary (29)
CLK1 / CLK (29)
Human (22)
Mouse (16)
Rat (3)
Bovine (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (4)
Orangutan (3)
Pig (3)
Rabbit (3)
IHC (5)
IHC-P (3)
WB (27)
ELISA (16)
ICC (1)
IF (8)
Peptide-ELISA (2)
rabbit (28)
mouse (1)
IgG (21)
polyclonal pc (29)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (16)
aa53-80 (7)
aa70-99 (7)
aa35-84 (4)
70-150 aa, Internal (1)
Arg126 (1)
Internal (1)
aa101-150 (1)
No (28)
Yes (1)
CLK1 / CLK Antibody - Western blot of CLK1 antibody
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CLK1 / CLK Rabbit anti-Human Polyclonal (70-150 aa, Internal) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CLK1 / CLK Antibody - CLK1 antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLK1 / CLK Rabbit anti-Human Polyclonal (aa35-84) Antibody
Human
WB
Unconjugated
100 µl/$424
CLK1 / CLK Antibody - Immunohistochemical analysis of CLK1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
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CLK1 / CLK Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CLK1 / CLK Antibody - Mouse Clk1 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The Clk1 antibody detected the Clk1 protein (arrow).
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CLK1 / CLK Rabbit anti-Mouse Polyclonal (aa53-80) Antibody
Mouse
WB
Unconjugated
400 µl/$393
CLK1 / CLK Antibody - Immunofluorescence analysis of HeLa cells.
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CLK1 / CLK Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CLK1 / CLK Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) at a concentration of 10 µg/ml.
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CLK1 / CLK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
CLK1 / CLK Antibody - Peptide - + Immunofluorescence analysis of HUVEC cells, using CLK1 antibody.
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CLK1 / CLK Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
CLK1 / CLK Antibody - Immunohistochemistry of paraffin-embedded human skeletal muscle tissue at dilution 1:100
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CLK1 / CLK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
CLK1 / CLK Antibody - Immunofluorescence analysis of HUVEC cells, using CLK1 Antibody. The picture on the right is blocked with the synthesized peptide.
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CLK1 / CLK Rabbit anti-Human Polyclonal (aa101-150) Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CLK1 / CLK Antibody - Staining 293 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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CLK1 / CLK Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
CLK1 / CLK Rabbit anti-Human Polyclonal (Arg126) Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
Select
CLK1 / CLK Rabbit anti-Mouse Polyclonal (aa53-80) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
Select
CLK1 / CLK Rabbit anti-Mouse Polyclonal (aa53-80) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
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CLK1 / CLK Rabbit anti-Mouse Polyclonal (aa53-80) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
Select
CLK1 / CLK Rabbit anti-Mouse Polyclonal (aa53-80) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
Select
CLK1 / CLK Rabbit anti-Mouse Polyclonal (aa53-80) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
CLK1 / CLK Rabbit anti-Mouse Polyclonal (aa53-80) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
Select
CLK1 / CLK Rabbit anti-Human Polyclonal (aa70-99) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
CLK1 / CLK Rabbit anti-Human Polyclonal (aa70-99) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
CLK1 / CLK Rabbit anti-Human Polyclonal (aa70-99) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
CLK1 / CLK Rabbit anti-Human Polyclonal (aa70-99) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
CLK1 / CLK Rabbit anti-Human Polyclonal (aa70-99) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
CLK1 / CLK Rabbit anti-Human Polyclonal (aa70-99) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
CLK1 / CLK Mouse anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$705
Select
CLK1 / CLK Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Viewing 1-25 of 29 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).