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CLIC4

chloride intracellular channel 4

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

Gene Name: chloride intracellular channel 4
Family/Subfamily: Ion Channel , Chloride channel - intracellular
Synonyms: CLIC4, CLIC4L, DKFZP566G223, Mc3s5, HuH1, MTCLIC, p64H1
Target Sequences: NM_013943 NP_039234.1 Q9Y696

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).