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CLEC5A / MDL-1

C-type lectin domain family 5, member A

Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

Gene Name:	C-type lectin domain family 5, member A
Synonyms:	CLEC5A, CLECSF5, MDL-1, MDL1
Target Sequences:	NM_013252 NP_037384.1 Q9NY25

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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