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Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
Gene Name: | C-type lectin domain family 5, member A |
Synonyms: | CLEC5A, CLECSF5, MDL-1, MDL1 |
Target Sequences: | NM_013252 NP_037384.1 Q9NY25 |
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