CLEC4M / L-SIGN / CD299

C-type lectin domain family 4, member M

CLEC4M / L-SIGN / CD299 is a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

CLEC4M / L-SIGN / CD299 (10)

Publications

No (10)

Tag

8His-DDK (Flag), N-terminus (1)

Fc (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (6)

Species

Human (8)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

Human (1)

Human Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (2)

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Human CLEC4M / L-SIGN / CD299 Protein (Recombinant His-T7) (aa242-399) - LS-G14199

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.3 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human CLEC4M / L-SIGN / CD299 Protein (Recombinant GST, N-terminus) (aa285-394) - LS-G61474

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CLEC4M / L-SIGN / CD299 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68760

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.2 kDa

Price:

20 µg/$1,107

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Human CLEC4M / L-SIGN / CD299 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68762

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.2 kDa

Price:

20 µg/$1,107

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Human CLEC4M / L-SIGN / CD299 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83023

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.2 kDa

Price:

20 µg/$150

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Human CLEC4M / L-SIGN / CD299 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83026

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.2 kDa

Price:

20 µg/$150

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Human CLEC4M / L-SIGN / CD299 Protein (Recombinant Fc) (Ser78-Glu399) - LS-G97374

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

65 kDa

Price:

100 µg/$926

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CLEC4M / L-SIGN / CD299 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101184

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.2 kDa

Price:

100 µg/$494

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CLEC4M / L-SIGN / CD299 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102626

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.2 kDa

Price:

100 µg/$494

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Human CLEC4M / L-SIGN / CD299 Protein (Recombinant 8His-DDK (Flag), N-terminus) - LS-G146128

Source:

Human

Tag:

8His-DDK (Flag), N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

37 kDa

Price:

10 µg/$307; 50 µg/$499

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