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CLDN8 / Claudin 8

claudin 8

CLDN8 / Claudin 8 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.

Gene Name: claudin 8
Family/Subfamily: Claudin , not assigned-Claudin
Synonyms: CLDN8, Claudin 8, Claudin-8
Target Sequences: NM_199328 AAH58004.1 P56748

Publications (1)

1
Glucocorticoids Regulate Tight Junction Permeability of Lung Epithelia by Modulating Claudin 8. Kielgast F, Schmidt H, Braubach P, Winkelmann VE, Thompson KE, Frick M, Dietl P, Wittekindt OH. American journal of respiratory cell and molecular biology. 2016 54:707-17. (ICC; Human) [Full Text Article] [PubMed:26473470] Related Antibodies: LS-B5505.

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Products
Antibodies (28)
Primary (28)
CLDN8 / Claudin 8 (28)
Human (21)
Mouse (8)
Rat (7)
Bovine (3)
Chimpanzee (3)
Dog (6)
Monkey (1)
IHC (14)
IHC-Fr (1)
IHC-P (7)
WB (25)
Flo (7)
ELISA (10)
IF (6)
Peptide-ELISA (2)
rabbit (27)
mouse (1)
Product Group
IHCPlus (3)
IgG (25)
polyclonal pc (28)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (15)
aa140-166 (7)
C-Terminus (5)
50-130 aa, Internal (1)
Internal (1)
aa141-225 (1)
aa81-130 (1)
No (27)
Yes (1)
CLDN8 / Claudin 8 Antibody - Anti-CLDN8 / Claudin 8 antibody IHC of rat colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CLDN8 / Claudin 8 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$485
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CLDN8 / Claudin 8 Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse, Dog, Rat
IHC, WB
HRP Conjugated
100 µl/$1,017
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CLDN8 / Claudin 8 Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse, Dog, Rat
IF, IHC, WB
Biotin Conjugated
100 µl/$1,017
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CLDN8 / Claudin 8 Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse, Dog, Rat
IF, IHC, WB
FITC Conjugated
100 µl/$1,017
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CLDN8 / Claudin 8 Rabbit anti-Mouse Polyclonal (PE) Antibody
Mouse, Dog, Rat
IF, IHC, WB
PE Conjugated
100 µl/$1,017
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CLDN8 / Claudin 8 Rabbit anti-Mouse Polyclonal (APC) Antibody
Mouse, Dog, Rat
IF, IHC, WB
APC Conjugated
100 µl/$1,017
CLDN8 / Claudin 8 Antibody - Anti-CLDN8 / Claudin 8 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (aa140-166) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
CLDN8 / Claudin 8 Antibody - Western blot analysis of extracts from Jurkat cells, using CLDN8 antibody.
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
CLDN8 / Claudin 8 Antibody - Anti-CLDN8 / Claudin 8 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
CLDN8 / Claudin 8 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Bovine, Human, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
CLDN8 / Claudin 8 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Bovine, Human, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
CLDN8 / Claudin 8 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Bovine, Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
CLDN8 / Claudin 8 Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (aa141-225) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
CLDN8 / Claudin 8 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (aa140-166) Antibody
Human
Flo, WB
Unconjugated
200 µl/$734
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (aa140-166) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (aa140-166) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
Select
CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (aa140-166) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (aa140-166) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (aa140-166) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
CLDN8 / Claudin 8 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using CLDN8 Polyclonal Antibody at dilution of 1:50.
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CLDN8 / Claudin 8 Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using CLDN8 Polyclonal Antibody at dilution of 1:50.
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (50-130 aa, Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CLDN8 / Claudin 8 Antibody - Western blot analysis of lysates from Jurkat cells, using CLDN8 Antibody. The lane on the right is blocked with the synthesized peptide.
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal (aa81-130) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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CLDN8 / Claudin 8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).